Jeffrey A Whitsett
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Explore the profile of Jeffrey A Whitsett including associated specialties, affiliations and a list of published articles.
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296
Citations
15727
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Recent Articles
1.
Kang M, Thomas S, Westley C, Blouin T, Xu L, Chan Y, et al.
Am J Respir Cell Mol Biol
. 2025 Jan;
PMID: 39805087
Surfactant protein-B (SP-B) deficiency is a lethal neonatal respiratory disease with few therapeutic options. Gene therapy using adeno-associated viruses (AAV) to deliver human cDNA (AAV-hSPB) can improve survival in a...
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Penrod S, Tang X, Moon C, Whitsett J, Naren A, Huang Y
Am J Physiol Gastrointest Liver Physiol
. 2024 Dec;
328(1):G72-G82.
PMID: 39641142
Membrane proteins, such as the cystic fibrosis transmembrane-conductance regulator (CFTR), play a crucial role in gastrointestinal functions and health. Endoplasmic reticulum (ER) membrane protein complex (EMC), a multi-subunit insertase, mediates...
4.
Li Q, Liao Y, Zeng J, Hu S, Li C, Whitsett J, et al.
Am J Respir Cell Mol Biol
. 2024 Nov;
PMID: 39556252
Tubulogenesis depends on precise cell shape changes driven by asymmetric tension from the actin cytoskeleton. How actin asymmetry is dynamically controlled to coordinate epithelial cell shape changes required for respiratory...
5.
Tang X, Wei W, Sun Y, Weaver T, Nakayasu E, Clair G, et al.
J Clin Invest
. 2024 Oct;
134(23).
PMID: 39405113
The most common mutation in surfactant protein C gene (SFTPC), SFTPCI73T, causes interstitial lung disease with few therapeutic options. We previously demonstrated that EMC3, an important component of the multiprotein...
6.
Gomez-Arroyo J, Houweling A, Bogaard H, Aman J, Kitzmiller J, Porollo A, et al.
bioRxiv
. 2024 Sep;
PMID: 39345371
Rationale: Approximately 80% of patients with non-familial pulmonary arterial hypertension (PAH) lack identifiable pathogenic genetic variants. While most genetic studies of PAH have focused on predicted loss-of-function variants, recent approaches...
7.
He H, Bell S, Davis A, Zhao S, Sridharan A, Na C, et al.
Nat Commun
. 2024 Sep;
15(1):8112.
PMID: 39284798
While the critical role of NKX2-1 and its transcriptional targets in lung morphogenesis and pulmonary epithelial cell differentiation is increasingly known, mechanisms by which chromatin accessibility alters the epigenetic landscape...
8.
Liu B, Sajiki Y, Sridharan A, Stuart W, Cui X, Siefert M, et al.
bioRxiv
. 2024 Sep;
PMID: 39229228
Delivery of modified mRNA encapsulated in lipid nanoparticles, exemplified by their successful use in COVID-19 vaccination, provides a framework for treating various genetic and acquired disorders. Herein, we developed PEGylated(PBAE-PEG)...
9.
Hao H, Maeda Y, Fukazawa T, Yamatsuji T, Takaoka M, Bao X, et al.
PLoS One
. 2024 Jul;
19(7):e0307052.
PMID: 38980851
[This corrects the article DOI: 10.1371/journal.pone.0071093.].
10.
Wang G, Wen B, Guo M, Li E, Zhang Y, Whitsett J, et al.
Nat Commun
. 2024 Jun;
15(1):5233.
PMID: 38898031
Mutations in the FOXF1 gene, a key transcriptional regulator of pulmonary vascular development, cause Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins, a lethal lung disease affecting newborns and infants....