Machiko Ikegami
Overview
Explore the profile of Machiko Ikegami including associated specialties, affiliations and a list of published articles.
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Articles
114
Citations
3314
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Recent Articles
1.
Uemasu K, Tanabe N, Tanimura K, Hasegawa K, Mizutani T, Hamakawa Y, et al.
Am J Respir Cell Mol Biol
. 2020 Feb;
63(1):67-78.
PMID: 32101459
Epithelial dysfunction in the small airways may cause the development of emphysema in chronic obstructive pulmonary disease. C/EBPα (CCAAT/enhancer binding protein-α), a transcription factor, is required for lung maturation during...
2.
Lin S, Ikegami M, Moon C, Naren A, Shannon J
J Biol Chem
. 2015 Jun;
290(30):18559-74.
PMID: 26048993
Pulmonary surfactant, a mixture of proteins and phospholipids, plays an important role in facilitating gas exchange by maintaining alveolar stability. Saturated phosphatidylcholine (SatPC), the major component of surfactant, is synthesized...
3.
Bridges J, Schehr A, Wang Y, Huo L, Besnard V, Ikegami M, et al.
PLoS One
. 2014 May;
9(5):e91376.
PMID: 24806461
Pulmonary surfactant is required for lung function at birth and throughout postnatal life. Defects in the surfactant system are associated with common pulmonary disorders including neonatal respiratory distress syndrome and...
4.
Madala S, Korfhagen T, Schmidt S, Davidson C, Edukulla R, Ikegami M, et al.
Am J Physiol Lung Cell Mol Physiol
. 2014 Feb;
306(8):L726-35.
PMID: 24508732
A number of growth factors and signaling pathways regulate matrix deposition and fibroblast proliferation in the lung. The epidermal growth factor receptor (EGFR) family of receptors and the transforming growth...
5.
Madala S, Edukulla R, Schmidt S, Davidson C, Ikegami M, Hardie W
Am J Respir Cell Mol Biol
. 2013 Nov;
50(4):777-86.
PMID: 24199692
Pulmonary fibrosis is caused by excessive proliferation and accumulation of stromal cells. Fibrocytes are bone marrow (BM)-derived cells that contribute to pathologic stromal cell accumulation in human lung disease. However,...
6.
Bridges J, Ludwig M, Mueller M, Kinzel B, Sato A, Xu Y, et al.
Am J Respir Cell Mol Biol
. 2013 Apr;
49(3):348-57.
PMID: 23590306
Pulmonary surfactant levels within the alveoli are tightly regulated to maintain lung volumes and promote efficient gas exchange across the air/blood barrier. Quantitative and qualitative abnormalities in surfactant are associated...
7.
Im S, Jeong H, Jeong H, Kim K, Hwang D, Ikegami M, et al.
PLoS One
. 2013 Mar;
8(3):e58511.
PMID: 23526992
Sorting nexin 5 (Snx5) has been posited to regulate the degradation of epidermal growth factor receptor and the retrograde trafficking of cation-independent mannose 6-phosphate receptor/insulin-like growth factor II receptor. Snx5...
8.
Sato A, Yamada N, Ogawa Y, Ikegami M
PLoS One
. 2013 Feb;
8(2):e57013.
PMID: 23437297
The transcription factor CCAAT/enhancer-binding protein α (C/EBPα) is a basic leucine zipper transcription factor and is expressed in alveolar type II cells, alveolar macrophages and Clara cells in the lung....
9.
Xu Y, Wang Y, Besnard V, Ikegami M, Wert S, Heffner C, et al.
PLoS One
. 2012 Aug;
7(8):e37046.
PMID: 22916088
The timing of lung maturation is controlled precisely by complex genetic and cellular programs. Lung immaturity following preterm birth frequently results in Respiratory Distress Syndrome (RDS) and Broncho-Pulmonary Dysplasia (BPD),...
10.
Ustiyan V, Wert S, Ikegami M, Wang I, Kalin T, Whitsett J, et al.
Dev Biol
. 2012 Aug;
370(2):198-212.
PMID: 22885335
Respiratory epithelial cells are derived from cell progenitors in the foregut endoderm that subsequently differentiate into the distinct cell types lining the conducting and alveolar regions of the lung. To...