Jeff C Liu
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Explore the profile of Jeff C Liu including associated specialties, affiliations and a list of published articles.
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30
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1750
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Recent Articles
1.
Jiang Z, Ju Y, Ali A, Chung P, Wang D, Liu J, et al.
Cancers (Basel)
. 2023 Nov;
15(22).
PMID: 38001575
The metastasis of tumor cells into vital organs is a major cause of death from diverse types of malignancies [...].
2.
Jiang Z, Ju Y, Ali A, Chung P, Skowron P, Wang D, et al.
Nat Commun
. 2023 Jul;
14(1):4313.
PMID: 37463901
Metastatic breast-cancer is a major cause of death in women worldwide, yet the relationship between oncogenic drivers that promote metastatic versus primary cancer is still contentious. To elucidate this relationship...
3.
Langille E, Al-Zahrani K, Ma Z, Liang M, Uuskula-Reimand L, Espin R, et al.
Cancer Discov
. 2022 Sep;
12(12):2930-2953.
PMID: 36108220
Significance: Infrequently mutated genes comprise most of the mutational burden in breast tumors but are poorly understood. In vivo CRISPR screening identified functional tumor suppressors that converged on epigenetic regulation....
4.
Andrews T, Atif J, Liu J, Perciani C, Ma X, Thoeni C, et al.
Hepatol Commun
. 2021 Nov;
6(4):821-840.
PMID: 34792289
The critical functions of the human liver are coordinated through the interactions of hepatic parenchymal and non-parenchymal cells. Recent advances in single-cell transcriptional approaches have enabled an examination of the...
5.
Gage B, Liu J, Innes B, MacParland S, McGilvray I, Bader G, et al.
Cell Stem Cell
. 2020 Jul;
27(2):254-269.e9.
PMID: 32640183
Liver sinusoidal endothelial cells (LSECs) form a highly specialized microvasculature that plays a critical role in liver function and disease. To better understand this role, we developed a strategy to...
6.
Chung P, Gendoo D, Ghanbari-Azarnier R, Liu J, Jiang Z, Tsui J, et al.
Nat Commun
. 2020 Apr;
11(1):1825.
PMID: 32286280
Pineoblastoma is a rare pediatric cancer induced by germline mutations in the tumor suppressors RB1 or DICER1. Presence of leptomeningeal metastases is indicative of poor prognosis. Here we report that...
7.
MacParland S, Liu J, Ma X, Innes B, Bartczak A, Gage B, et al.
Nat Commun
. 2018 Oct;
9(1):4383.
PMID: 30348985
The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the human...
8.
Zacksenhaus E, Liu J, Granieri L, Vorobieva I, Wang D, Ghanbari-Azarnier R, et al.
Mol Cell Oncol
. 2018 Sep;
5(4):e1481814.
PMID: 30250928
The dual phosphatase CDC25 has recently been identified as a target for diverse triple-negative breast cancers including -deficient tumors. Moreover, CDC25 inhibitors effectively synergize with PI3K inhibitors to suppress tumor...
9.
Liu J, Granieri L, Shrestha M, Wang D, Vorobieva I, Rubie E, et al.
Cell Rep
. 2018 Apr;
23(1):112-126.
PMID: 29617654
CDK4/6 inhibitors are effective against cancer cells expressing the tumor suppressor RB1, but not RB1-deficient cells, posing the challenge of how to target RB1 loss. In triple-negative breast cancer (TNBC),...
10.
Zacksenhaus E, Shrestha M, Liu J, Vorobieva I, Chung P, Ju Y, et al.
Trends Cancer
. 2017 Nov;
3(11):768-779.
PMID: 29120753
A switch from catabolic to anabolic metabolism, a major hallmark of cancer, enables rapid cell duplication, and is driven by multiple oncogenic alterations, including PIK3CA mutation, MYC amplification, and TP53...