Jedd Hillegass
Overview
Explore the profile of Jedd Hillegass including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
174
Followers
0
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Recent Articles
1.
Parris P, Whelan G, Chilton M, Beaumont C, Burild A, Bruen U, et al.
Regul Toxicol Pharmacol
. 2025 Jan;
157:105776.
PMID: 39884453
The Extractables and Leachables Safety Information Exchange (ELSIE) Consortium added to the sensitization potency analysis of Parris et al. (2023) by including the Product Quality Research Institute (PQRI) extractable and...
2.
Graham J, Anand S, Bercu J, Besenhofer L, de Zafra C, Feng Y, et al.
Regul Toxicol Pharmacol
. 2024 Sep;
153:105700.
PMID: 39243930
Protein A (PA) is a bacterial cell wall component of Staphylococcus aureus whose function is to bind to Immunoglobulin G (IgG). Given its ability to bind IgG as well as...
3.
Kostal J, Voutchkova-Kostal A, Bercu J, Graham J, Hillegass J, Masuda-Herrera M, et al.
Chem Res Toxicol
. 2024 Jul;
37(8):1404-1414.
PMID: 39069667
Skin sensitization is a critical end point in occupational toxicology that necessitates the use of fast, accurate, and affordable models to aid in establishing handling guidance for worker protection. While...
4.
Masuda-Herrera M, Rosen H, Burild A, Broschard T, Bell T, Graham J, et al.
Regul Toxicol Pharmacol
. 2023 Sep;
145:105494.
PMID: 37748702
Health-based exposure limits (HBELs) are derived for leachables from polymeric components that interact with the drug substance which exceed a safety concern threshold (SCT). However, given the nature of leachables,...
5.
Macmillan D, Chilton M, Hillegass J
Regul Toxicol Pharmacol
. 2022 Nov;
137:105292.
PMID: 36400282
In silico models are often built solely on publicly available data which may mean that they are less predictive for proprietary chemical space. Data sharing initiatives can improve the performance...
6.
Graham J, Trejo-Martin A, Chilton M, Kostal J, Bercu J, Beutner G, et al.
Chem Res Toxicol
. 2022 May;
35(6):1011-1022.
PMID: 35532537
Peptide couplers (also known as amide bond-forming reagents or coupling reagents) are broadly used in organic chemical syntheses, especially in the pharmaceutical industry. Yet, occupational health hazards associated with this...
7.
Graham J, Rodas M, Hillegass J, Schulze G
Regul Toxicol Pharmacol
. 2020 Nov;
119:104816.
PMID: 33166621
Acute oral toxicity (AOT) information is utilized to categorize compounds according to the severity of their hazard and used to inform risk assessments for human health and the environment. Given...
8.
Graham J, Hillegass J, Schulze G
Regul Toxicol Pharmacol
. 2020 Nov;
118:104813.
PMID: 33144077
In order to develop new and effective medicines, pharmaceutical companies must be modality agnostic. As science reveals an enhanced understanding of biological processes, new therapeutic modalities are becoming important in...
9.
Johnson C, Ahlberg E, Anger L, Beilke L, Benigni R, Bercu J, et al.
Regul Toxicol Pharmacol
. 2020 Jul;
116:104688.
PMID: 32621976
The assessment of skin sensitization has evolved over the past few years to include in vitro assessments of key events along the adverse outcome pathway and opportunistically capitalize on the...
10.
Hasselgren C, Ahlberg E, Akahori Y, Amberg A, Anger L, Atienzar F, et al.
Regul Toxicol Pharmacol
. 2019 Jun;
107:104403.
PMID: 31195068
In silico toxicology (IST) approaches to rapidly assess chemical hazard, and usage of such methods is increasing in all applications but especially for regulatory submissions, such as for assessing chemicals...