Jean Grisouard
Overview
Explore the profile of Jean Grisouard including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
471
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Recent Articles
1.
Grisouard J, Li S, Kubovcakova L, Rao T, Meyer S, Lundberg P, et al.
Blood
. 2016 Jun;
128(6):839-51.
PMID: 27288519
Mutations in JAK2 exon 12 are frequently found in patients with polycythemia vera (PV) that do not carry a JAK2-V617F mutation. The majority of these patients display isolated erythrocytosis. We...
2.
Skoda R, Duek A, Grisouard J
Exp Hematol
. 2015 Jul;
43(8):599-608.
PMID: 26209551
Major progress has been recently made in understanding the molecular pathogenesis of myeloproliferative neoplasms (MPN). Mutations in one of four genes-JAK2, MPL, CALR, and CSF3R-can be found in the vast...
3.
Hammaren H, Ungureanu D, Grisouard J, Skoda R, Hubbard S, Silvennoinen O
Proc Natl Acad Sci U S A
. 2015 Apr;
112(15):4642-7.
PMID: 25825724
Pseudokinases lack conserved motifs typically required for kinase activity. Nearly half of pseudokinases bind ATP, but only few retain phosphotransfer activity, leaving the functional role of nucleotide binding in most...
4.
Grisouard J, Shimizu T, Duek A, Kubovcakova L, Hao-Shen H, Dirnhofer S, et al.
Blood
. 2015 Jan;
125(13):2131-40.
PMID: 25595737
The acquired somatic JAK2-V617F mutation is present in >80% of patients with myeloproliferative neoplasms (MPNs). Stat3 plays a role in hematopoietic homeostasis and might influence the JAK2-V617F-driven MPN phenotype. We...
5.
Duek A, Lundberg P, Shimizu T, Grisouard J, Karow A, Kubovcakova L, et al.
Blood
. 2014 May;
123(25):3943-50.
PMID: 24820309
The interferon-γ (IFNγ)/signal transducer and activator of transcription 1 (Stat1) pathway shows higher activity in patients with essential thrombocythemia (ET) than in polycythemia vera (PV) and was proposed to be...
6.
Grisouard J, Hao-Shen H, Dirnhofer S, Wagner K, Skoda R
Haematologica
. 2014 Feb;
99(4):e52-4.
PMID: 24510341
No abstract available.
7.
Grisouard J, Ojeda-Uribe M, Looser R, Hao-Shen H, Lundberg P, Duek A, et al.
Blood
. 2013 Nov;
122(22):3694-6.
PMID: 24263960
No abstract available.
8.
Kubovcakova L, Lundberg P, Grisouard J, Hao-Shen H, Romanet V, Andraos R, et al.
Blood
. 2012 Dec;
121(7):1188-99.
PMID: 23264594
To establish a preclinical animal model for testing drugs with potential effects on myeloproliferative neoplasms (MPNs), we first performed a detailed phenotypic characterization of Cre-inducible transgenic JAK2-V617F mice. Deleting the...
9.
Timper K, Grisouard J, Sauter N, Herzog-Radimerski T, Dembinski K, Peterli R, et al.
Am J Physiol Endocrinol Metab
. 2012 Oct;
304(1):E1-13.
PMID: 23092914
Obesity-related insulin resistance is linked to a chronic state of systemic and adipose tissue-derived inflammation. Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone also acting on adipocytes. We investigated whether...
10.
Grisouard J, Dembinski K, Mayer D, Keller U, Muller B, Christ-Crain M
Diabetol Metab Syndr
. 2011 Jul;
3:16.
PMID: 21774820
Background: Adipokines, e.g. TNFα, IL-6 and leptin increase insulin resistance, and consequent hyperinsulinaemia influences breast cancer progression. Beside its mitogenic effects, insulin may influence adipokine production from adipocyte stromal cells...