Jean D Beggs
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Explore the profile of Jean D Beggs including associated specialties, affiliations and a list of published articles.
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52
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1837
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Recent Articles
1.
Strader L, Staller M, Willis A, Faulkner G, Beggs J, Cech T
Mol Cell
. 2023 Feb;
83(3):320-323.
PMID: 36736305
The Central Dogma has been a useful conceptualization of the transfer of genetic information, and our understanding of the detailed mechanisms involved in that transfer continues to evolve. Here, we...
2.
Maudlin I, Beggs J
RNA Biol
. 2021 Oct;
18(sup2):782-793.
PMID: 34705599
From yeast to humans, pre-mRNA splicing occurs mainly co-transcriptionally, with splicing and transcription functionally coupled such that they influence one another. The recruitment model of co-transcriptional splicing proposes that core...
3.
Aslanzadeh V, Beggs J
RNA
. 2020 May;
26(9):1081-1085.
PMID: 32439718
We reported previously that, in budding yeast, transcription rate affects both the efficiency and fidelity of pre-mRNA splicing, especially of ribosomal protein transcripts. Here, we report that the majority of...
4.
Mendoza-Ochoa G, Barrass J, Maudlin I, Beggs J
RNA Biol
. 2019 Nov;
16(12):1775-1784.
PMID: 31671032
Pre-messenger RNA splicing involves multi-step assembly of the large spliceosome complexes that catalyse the two consecutive trans-esterification reactions, resulting in intron removal. There is evidence that proof-reading mechanisms monitor the...
5.
Barrass J, Beggs J
J Vis Exp
. 2019 Sep;
(150).
PMID: 31498317
The nucleotide analogue, 4-thiouracil (4tU), is readily taken up by cells and incorporated into RNA as it is transcribed in vivo, allowing isolation of the RNA produced during a brief...
6.
Barrass J, Mendoza-Ochoa G, Maudlin I, Sani E, Beggs J
J Vis Exp
. 2019 Aug;
(149).
PMID: 31380835
The plant auxin binding receptor, TIR1, recognizes proteins containing a specific auxin-inducible degron (AID) motif in the presence of auxin, targeting them for degradation. This system is exploited in many...
7.
Maudlin I, Beggs J
RNA
. 2019 Jul;
25(10):1298-1310.
PMID: 31289129
There is increasing evidence from yeast to humans that pre-mRNA splicing occurs mainly cotranscriptionally, such that splicing and transcription are functionally coupled. Currently, there is little insight into the contribution...
8.
Gautam A, Beggs J
RNA Biol
. 2019 Jan;
16(2):185-195.
PMID: 30672374
Snu114, a component of the U5 snRNP, plays a key role in activation of the spliceosome. It controls the action of Brr2, an RNA-stimulated ATPase/RNA helicase that disrupts U4/U6 snRNA...
9.
Mendoza-Ochoa G, Barrass J, Terlouw B, Maudlin I, de Lucas S, Sani E, et al.
Yeast
. 2018 Oct;
36(1):75-81.
PMID: 30375036
The auxin-inducible degron (AID) is a useful technique to rapidly deplete proteins of interest in nonplant eukaryotes. Depletion is achieved by addition of the plant hormone auxin to the cell...
10.
Tudek A, Schmid M, Makaras M, Barrass J, Beggs J, Jensen T
Cell Rep
. 2018 Aug;
24(9):2457-2467.e7.
PMID: 30157437
Genomes are promiscuously transcribed, necessitating mechanisms that facilitate the sorting of RNA for function or destruction. The polyA (pA) tail is one such distinguishing feature, which in the Saccharomyces cerevisiae...