Richard J Grainger
Overview
Explore the profile of Richard J Grainger including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
330
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Recent Articles
1.
Gautam A, Grainger R, Vilardell J, Barrass J, Beggs J
Nucleic Acids Res
. 2015 Mar;
43(6):3309-17.
PMID: 25740649
Pre-mRNA splicing involves two transesterification steps catalyzed by the spliceosome. How RNA substrates are positioned in each step and the molecular rearrangements involved, remain obscure. Here, we show that mutations...
2.
Grainger R, Barrass J, Jacquier A, Rain J, Beggs J
RNA
. 2009 Oct;
15(12):2161-73.
PMID: 19854871
In Saccharomyces cerevisiae, Cwc21p is a protein of unknown function that is associated with the NineTeen Complex (NTC), a group of proteins involved in activating the spliceosome to promote the...
3.
Ivings L, Towns K, Matin M, Taylor C, Ponchel F, Grainger R, et al.
Mol Vis
. 2008 Dec;
14:2357-66.
PMID: 19096719
Purpose: Retinitis pigmentosa (RP) is caused by mutations in a variety of genes, most of which have known functions in the retina. However, one of the most perplexing findings of...
4.
Boon K, Grainger R, Ehsani P, Barrass J, Auchynnikava T, Inglehearn C, et al.
Nat Struct Mol Biol
. 2007 Oct;
14(11):1077-83.
PMID: 17934474
Prp8 protein (Prp8p) is a highly conserved pre-mRNA splicing factor and a component of spliceosomal U5 small nuclear ribonucleoproteins (snRNPs). Although it is ubiquitously expressed, mutations in the C terminus...
5.
Boon K, Norman C, Grainger R, Newman A, Beggs J
RNA
. 2005 Dec;
12(2):198-205.
PMID: 16373487
We describe a novel approach to characterize the functional domains of a protein in vivo. This involves the use of a custom-built Tn5-based transposon that causes the expression of a...
6.
Grainger R, Beggs J
RNA
. 2005 Apr;
11(5):533-57.
PMID: 15840809
Pre-messenger RNA (pre-mRNA) splicing is a central step in gene expression. Lying between transcription and protein synthesis, pre-mRNA splicing removes sequences (introns) that would otherwise disrupt the coding potential of...