Jean-Pierre Gesson
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Explore the profile of Jean-Pierre Gesson including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
58
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Recent Articles
1.
Khodair A, Awad M, Gesson J, Elshaier Y
Carbohydr Res
. 2019 Dec;
487:107894.
PMID: 31865252
N-ribosylation and N-mannosylation compounds have a great role in compounds activity as anticancer. The reaction of 2-thioxo-4-thiazolidinone (rhodanine) derivatives, as aglycon part, was done with ribofuranose and mannopyranose sugars (glycone...
2.
Khodair A, Gesson J
Carbohydr Res
. 2011 Nov;
346(18):2831-7.
PMID: 22088884
N- and S-galactosylation was carried out via the reaction of 5-((Z)-arylidene)-2-thioxo-4-thiazolidinones with 2,3,4,6-tetra-O-acetyl-α-d-galactopyranosyl bromide under alkaline conditions or under silylation conditions. Deacetylation of the N-galactosylation products was performed with concentrated...
3.
Charrier C, Clarhaut J, Gesson J, Estiu G, Wiest O, Roche J, et al.
J Med Chem
. 2009 Apr;
52(9):3112-5.
PMID: 19385600
New benzofuranones were synthesized and evaluated toward NCI-H661 non-small cell lung cancer cells. Benzamide derivatives possessed micromolar antiproliferative and histone deacetylase inhibitory activities and modulate histone H4 acetylation. Hydroxamic acids...
4.
Thomas M, Clarhaut J, Tranoy-Opalinski I, Gesson J, Roche J, Papot S
Bioorg Med Chem
. 2008 Aug;
16(17):8109-16.
PMID: 18692397
Two glucuronide prodrugs of the histone deacetylase inhibitor CI-994 were synthesized. These compounds were found to be soluble in aqueous media and stable under physiological conditions. The carbamoyl derivatisation of...
5.
Cantet A, Carreyre H, Gesson J, Jouannetaud M, Renoux B
J Org Chem
. 2008 Mar;
73(7):2875-8.
PMID: 18315004
A variety of alkynylated amines, amides, and imides are reacted in the superacid system HF-SbF5 to give regioselectively new beta-gem-difluoroamines. The reaction, which is not observed in pure HF, is...
6.
Charrier C, Roche J, Gesson J, Bertrand P
Bioorg Med Chem Lett
. 2007 Sep;
17(22):6142-6.
PMID: 17897824
New compounds derived from inhibitors of histone deacetylases (HDACs) have been synthesized and their antiproliferative activities towards non small lung cancer cell line H661 evaluated. Their design is based on...
7.
Loudni L, Roche J, Potiron V, Clarhaut J, Bachmann C, Gesson J, et al.
Bioorg Med Chem Lett
. 2007 Jul;
17(17):4819-23.
PMID: 17624773
New histone deacetylase inhibitors have been synthesized and evaluated for their activity against non-small lung cancer cell line H661. These compounds have been designed with diversely substituted 1,4-benzodiazepine-2,5-dione moieties as...
8.
Thomas M, Gesson J, Papot S
J Org Chem
. 2007 May;
72(11):4262-4.
PMID: 17465568
The first O-glycosylation of hydroxamic acids is reported. This process involves the use of glycosyl N-phenyl trifluoroacetimidates as glycosyl donors in the presence TMSOTf and 4 A molecular sieves in...
9.
Thomas M, Rivault F, Tranoy-Opalinski I, Roche J, Gesson J, Papot S
Bioorg Med Chem Lett
. 2006 Dec;
17(4):983-6.
PMID: 17157009
The beta-O-glucuronide and beta-O-galactoside of SAHA have been prepared and evaluated as prodrugs for selective cancer chemotherapy (ADEPT, PMT). These new compounds are stable under physiological conditions and do not...
10.
Charrier C, Bertrand P, Gesson J, Roche J
Bioorg Med Chem Lett
. 2006 Aug;
16(20):5339-44.
PMID: 16904890
New inhibitors of histone deacetylase (HDAC) have been synthesized and evaluated for their activity toward non small lung cancer cell line H661. Their design is based on indanone (or tetralone)...