Jean-Guy Delcros
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Explore the profile of Jean-Guy Delcros including associated specialties, affiliations and a list of published articles.
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52
Citations
802
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Recent Articles
1.
Grenier D, Gelin M, Yang Y, Yang Cbs Cnrs Fr Y, Mularoni A, Guichou J, et al.
ChemMedChem
. 2025 Jan;
:e202400868.
PMID: 39835439
The serine/threonine protein kinase CK2, a tetramer composed of a regulatory dimer (CK2β) bound to two catalytic subunits CK2α, is a well-established therapeutic target for various pathologies, including cancer and...
2.
Breusa S, Thomas E, Baldinotti N, Zilio S, Delcros J, Hernandez-Palomino D, et al.
Biomater Adv
. 2024 May;
161:213881.
PMID: 38749213
Nanoparticle's success as drug delivery systems for cancer treatment has been achieved through passive targeting mechanisms. However, tumor heterogeneity and rapid drug clearance limit the treatment efficacy. Improved outcomes and...
3.
Bancet A, Frem R, Jeanneret F, Mularoni A, Bazelle P, Roelants C, et al.
iScience
. 2024 Feb;
27(2):108903.
PMID: 38318383
Although the involvement of protein kinase CK2 in cancer is well-documented, there is a need for selective CK2 inhibitors suitable for investigating CK2 specific roles in cancer-related biological pathways and...
4.
Kryza D, Wischhusen J, Richaud M, Hervieu M, Sidi Boumedine J, Delcros J, et al.
EMBO Mol Med
. 2023 Mar;
15(4):e16732.
PMID: 36876343
Targeted radionuclide therapy is a revolutionary tool for the treatment of highly spread metastatic cancers. Most current approaches rely on the use of vectors to deliver radionuclides to tumor cells,...
5.
Gorny H, Mularoni A, Delcros J, Freton C, Preto J, Krimm I
J Enzyme Inhib Med Chem
. 2023 Jan;
38(1):2121821.
PMID: 36650907
The mitochondrial voltage-dependent anion channel 1 (VDAC1) plays a central role in metabolism and apoptosis, which makes it a promising therapeutic target. Nevertheless, molecular mechanisms governing VDAC1 functioning remain unclear....
6.
Dobrovolskaite A, Gardner R, Delcros J, Phanstiel 4th O
ACS Med Chem Lett
. 2022 Feb;
13(2):319-326.
PMID: 35178189
Nine- and twelve-membered triaza-macrocycles were appended to one end of homospermidine to make polyamine lassos. These compounds were shown to be potent polyamine transport inhibitors (PTIs) using pancreatic ductal adenocarcinoma...
7.
Jiang S, Richaud M, Vieugue P, Rama N, Delcros J, Siouda M, et al.
EMBO Mol Med
. 2021 Mar;
13(4):e12878.
PMID: 33719214
The navigation cue netrin-1 is well-documented for its key role in cancer development and represents a promising therapeutic target currently under clinical investigation. Phase 1 and 2 clinical trials are...
8.
Bissey P, Mathot P, Guix C, Jasmin M, Goddard I, Costechareyre C, et al.
Cancer Res
. 2020 Feb;
80(10):1970-1980.
PMID: 32060146
The Sonic Hedgehog (SHH) pathway plays a key role in cancer. Alterations of SHH canonical signaling, causally linked to tumor progression, have become rational targets for cancer therapy. However, Smoothened...
9.
Wischhusen J, Wilson K, Delcros J, Molina-Pena R, Gibert B, Jiang S, et al.
Theranostics
. 2018 Nov;
8(18):5126-5142.
PMID: 30429890
In ultrasound molecular imaging (USMI), ligand-functionalized microbubbles (MBs) are used to visualize vascular endothelial targets. Netrin-1 is upregulated in 60% of metastatic breast cancers and promotes tumor progression. A novel...
10.
Lin S, Negulescu A, Bulusu S, Gibert B, Delcros J, Ducarouge B, et al.
Nat Commun
. 2017 Jul;
8:16074.
PMID: 28719575
Notch signalling is a causal determinant of cancer and efforts have been made to develop targeted therapies to inhibit the so-called canonical pathway. Here we describe an unexpected pro-apoptotic role...