Jayalakshmi Sridhar
Overview
Explore the profile of Jayalakshmi Sridhar including associated specialties, affiliations and a list of published articles.
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35
Citations
369
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Recent Articles
1.
Thornton A, Komati R, Kim H, Myers J, Petty K, Sam R, et al.
Front Mol Biosci
. 2025 Jan;
11():1481912.
PMID: 39749216
Introduction: Many breast cancer therapeutics target the PI3K/AKT/mTOR oncogenic pathway. Development of resistance to the therapeutics targeting this pathway is a frequent occurrence. Therapeutics targeting p70S6K1, a downstream member of...
2.
Sridhar J, Goloverda G
J Chem Educ
. 2024 Nov;
101(11):4680-4685.
PMID: 39554209
Molecular Structure and Organic Synthesis (MSOS) is an upper-division undergraduate (capstone) laboratory course for undergraduates majoring in chemistry at Xavier University of Louisiana (XULA). The course is designed for juniors...
3.
Galla S, Sridhar J, Mague J, Zhang X, White K, Zhang Q, et al.
Acta Crystallogr E Crystallogr Commun
. 2024 Aug;
80(Pt 8):873-877.
PMID: 39108777
In the title mol-ecule, CHBrO, the di-hydro-indene moiety is essentially planar but with a slight twist in the saturated portion of the five-membered ring. The meth-oxy groups lie close to...
4.
Goyal N, Do C, Sridhar J, Shaik S, Thompson A, Perry T, et al.
Chem Res Toxicol
. 2023 Nov;
36(12):1973-1979.
PMID: 37963190
As a potential means for smoking cessation and consequently prevention of smoking-related diseases and mortality, in this study, our goal was to investigate the inhibition of nicotine metabolism by P450...
5.
Goyal N, Do C, Hill-Odom M, Beamon T, Ponnapakkam T, Liu J, et al.
J Oncol Res Ther
. 2023 Aug;
8(2).
PMID: 37538786
Background: Many current anti-cancer drugs used to treat breast cancer mediate tumor cell death through the induction of apoptosis. Cancer cells, however, often acquire multidrug-resistance following prolonged exposure to chemotherapeutics....
6.
Goyal N, Sridhar J, Do C, Bratton M, Shaik S, Jiang Q, et al.
J Cancer Metastasis Treat
. 2021 Nov;
7.
PMID: 34722929
Aim: In this study, our goal was to study the inhibition of nicotine metabolism by P450 2A6, as a means for reduction in tobacco use and consequently the prevention of...
7.
Schroeder R, Sfondouris M, Goyal N, Komati R, Weerathunga A, Gettridge C, et al.
ACS Omega
. 2019 Aug;
4(6):10610-10619.
PMID: 31460159
Human epidermal growth factor receptor 2 (HER2) is overexpressed in nearly 20-30% of breast cancers and is associated with metastasis resulting in poor patient survival and high recurrence. The dual...
8.
DESIGN AND SYNTHESIS OF DIBENZYLFURAN BASED ETHER AND ESTER DERIVATIVES AS POTENTIAL P450 INHIBITORS
Goyal N, Bongay-Williams K, Do C, Perry T, Kantrow E, Hill-Odom M, et al.
J Undergrad Chem Res
. 2019 Aug;
17(4):102-104.
PMID: 31363349
Cytochrome P450 enzymes are a superfamily of hemoproteins involved in the metabolism and detoxification of endogenous and exogenous compounds. P450s are involved in the bioactivation of certain procarcinogens leading to...
9.
Foroozesh M, Sridhar J, Goyal N, Liu J
Molecules
. 2019 Apr;
24(8).
PMID: 31022888
Cytochrome P450 enzymes (CYPs) are important phase I enzymes involved in the metabolism of endogenous and xenobiotic compounds mainly through mono-oxygenation reactions into more polar and easier to excrete species....
10.
Jha V, Goyal N, Stevens C, Stevens E, Sridhar J
J Org Chem
. 2017 Nov;
82(24):13686-13692.
PMID: 29111723
We have discovered a transition-metal-free approach to the synthesis of 2,2'-bis(naphthoquinones) using a Diels-Alder reaction of conjugated ketene silyl acetals with benzoquinone. Its monomer analogue can also be synthesized by...