Coumarins and P450s, Studies Reported To-Date

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2019 Apr 27

PMID 31022888

Citations 8

Authors

Maryam Foroozesh

Jayalakshmi Sridhar

Navneet Goyal

Jiawang Liu

Affiliations

Soon will be listed here.

Abstract

Cytochrome P450 enzymes (CYPs) are important phase I enzymes involved in the metabolism of endogenous and xenobiotic compounds mainly through mono-oxygenation reactions into more polar and easier to excrete species. In addition to their role in detoxification, they play important roles in the biosynthesis of endogenous compounds and the bioactivation of xenobiotics. Coumarins, phytochemicals abundant in food and commonly used in fragrances and cosmetics, have been shown to interact with P450 enzymes as substrates and/or inhibitors. In this review, these interactions and their significance in pharmacology and toxicology are discussed in detail.

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