Jason Stumpff
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Explore the profile of Jason Stumpff including associated specialties, affiliations and a list of published articles.
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42
Citations
1109
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Recent Articles
1.
Phillips A, Zhang R, Jaffe M, Schulz R, Carty M, Verma A, et al.
Nat Commun
. 2025 Jan;
16(1):307.
PMID: 39747049
Chromosome instability is a prevalent vulnerability of cancer cells that has yet to be fully exploited therapeutically. To identify genes uniquely essential to chromosomally unstable cells, we mined the Cancer...
2.
Day C, Grigore F, Hakkim F, Paul S, Langfald A, Weberg M, et al.
Curr Biol
. 2024 Dec;
35(2):354-362.e7.
PMID: 39729988
Serine 31 is a phospho-site unique to the histone H3.3 variant; mitotic phospho-Ser31 is restricted to pericentromeric heterochromatin, and disruption of phospho-Ser31 results in chromosome segregation defects and loss of...
3.
Nesbit C, Martin W, Czechanski A, Byers C, Raghupathy N, Ferraj A, et al.
bioRxiv
. 2024 Dec;
PMID: 39677807
The kinesin family member 18A () is an essential regulator of microtubule dynamics and chromosome alignment during mitosis. Functional dependency on KIF18A varies by cell type and genetic context but...
4.
Schutt K, Queen K, Fisher K, Budington O, Mao W, Liu W, et al.
Front Mol Biosci
. 2024 Feb;
11:1328077.
PMID: 38410188
The mitotic kinesin, KIF18A, is required for proliferation of cancer cells that exhibit chromosome instability (CIN), implicating it as a promising target for treatment of a subset of aggressive tumor...
5.
Schutt K, Queen K, Fisher K, Budington O, Mao W, Liu W, et al.
bioRxiv
. 2023 Oct;
PMID: 37905069
The mitotic kinesin, KIF18A, is required for proliferation of cancer cells that exhibit chromosome instability (CIN), implicating it as a promising target for treatment of a subset of aggressive tumor...
6.
Queen K, Cario A, Berger C, Stumpff J
Mol Biol Cell
. 2023 Oct;
35(1):ar3.
PMID: 37903223
Kinesins support many diverse cellular processes, including facilitating cell division through mechanical regulation of the mitotic spindle. However, how kinesin activity is controlled to facilitate this process is not well...
7.
Queen K, Cario A, Berger C, Stumpff J
bioRxiv
. 2023 May;
PMID: 37205510
Kinesins support many diverse cellular processes, including facilitating cell division through mechanical regulation of the mitotic spindle. However, how kinesin activity is controlled to facilitate this process is not well...
8.
Thompson A, Blackburn P, Arons N, Stevens S, Babovic-Vuksanovic D, Lian J, et al.
Elife
. 2022 Jun;
11.
PMID: 35730929
The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain of KIF22 have been identified in patients with...
9.
Thompson A, Vandal S, Stumpff J
Methods Mol Biol
. 2022 Jan;
2415:139-149.
PMID: 34972951
The chromokinesin KIF22 (Kid, kinesin-10 family) is the primary generator of polar ejection forces, which contribute to chromosome positioning and alignment in mitotic cells. Assessment of KIF22 function requires quantitative...
10.
Solon A, Tan Z, Schutt K, Jepsen L, Haynes S, Nesvizhskii A, et al.
Sci Adv
. 2021 Nov;
7(47):eabj9812.
PMID: 34797717
Kinesins are regulated in space and time to ensure activation only in the presence of cargo. Kinesin-binding protein (KIFBP), which is mutated in Goldberg-Shprintzen syndrome, binds to and inhibits the...