Jason S Tedrow
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Explore the profile of Jason S Tedrow including associated specialties, affiliations and a list of published articles.
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14
Citations
151
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Recent Articles
1.
Davis C, Ichiishi N, Burke B, Tedrow J
J Org Chem
. 2025 Jan;
90(5):1905-1911.
PMID: 39847341
Imidates are versatile synthetic intermediates that contain ambiphilic reactivity, making them valuable pharmaceutically relevant synthons. Despite their extensive utility, imidates are typically generated in situ rather than isolated due to...
2.
Caille S, Cui S, Faul M, Mennen S, Tedrow J, Walker S
J Org Chem
. 2019 Mar;
84(8):4583-4603.
PMID: 30916557
A Perspective of our work in the development of innovative synthetic methods within the discipline of Process Research and Development is presented. Through an overview of some of the programs...
3.
Chen Y, Huang J, Hwang T, Chen M, Tedrow J, Farrell R, et al.
Org Lett
. 2015 Jun;
17(12):2948-51.
PMID: 26037223
A highly efficient and regioselective halogenation reaction of unsymmetrical pyridine N-oxide under mild conditions is described. The methodology provides a practical access to various 2-halo-substituted pyridines, which are pharmaceutically important...
4.
Farrell R, Silva Elipe M, Bartberger M, Tedrow J, Vounatsos F
Org Lett
. 2012 Dec;
15(1):168-71.
PMID: 23234245
A process for the regioselective amination of unsymmetrical 3,5-substituted pyridine N-oxides has been developed utilizing cheap, readily available saccharin as an ammonium surrogate. High conversions of the corresponding saccharin adducts...
5.
Zigterman J, Woo J, Walker S, Tedrow J, Borths C, Bunel E, et al.
J Org Chem
. 2007 Oct;
72(23):8870-6.
PMID: 17927253
A variety of 4-oxobutenamides 1 were subjected to rhodium-catalyzed conjugate addition with arylboronic acids providing high regio- and enantioselectivity (97:3 to >99:1, >96% ee) and moderate to excellent yields (54-99%)....
6.
Wang G, Mantei R, Kawai M, Tedrow J, Barnes D, Wang J, et al.
Bioorg Med Chem Lett
. 2007 Mar;
17(10):2817-22.
PMID: 17350258
A series of aryl sulfonamides of 5,6-disubstituted anthranilic acids were identified as potent inhibitors of methionine aminopeptidase-2 (MetAP2). Small alkyl groups and 3-furyl were tolerated at the 5-position of anthranilic...
7.
Colyer J, Andersen N, Tedrow J, Soukup T, Faul M
J Org Chem
. 2006 Aug;
71(18):6859-62.
PMID: 16930038
A variety of N-tert-butanesulfinyl imines were reduced with NaBH4 in THF containing 2% water to provide the corresponding secondary sulfinamides in high yield and diastereoselectivity. By using the same sulfinyl...
8.
Sheppard G, Wang J, Kawai M, Fidanze S, Bamaung N, Erickson S, et al.
J Med Chem
. 2006 Jun;
49(13):3832-49.
PMID: 16789740
Methionine aminopeptidase-2 (MetAP2) is a novel target for cancer therapy. As part of an effort to discover orally active reversible inhibitors of MetAP2, a series of anthranilic acid sulfonamides with...
9.
Kawai M, Bamaung N, Fidanze S, Erickson S, Tedrow J, Sanders W, et al.
Bioorg Med Chem Lett
. 2006 Apr;
16(13):3574-7.
PMID: 16632353
We have screened molecules for inhibition of MetAP2 as a novel approach toward antiangiogenesis and anticancer therapy using affinity selection/mass spectrometry (ASMS) employing MetAP2 loaded with Mn(2+) as the active...
10.
Evans D, Michael F, Tedrow J, Campos K
J Am Chem Soc
. 2003 Mar;
125(12):3534-43.
PMID: 12643715
Chiral mixed phosphorus/sulfur ligands 1-3 have been shown to be effective in enantioselective Rh-catalyzed dehydroamino acid hydrogenation and ketone hydrosilylation reactions (eqs 1, 2). After assaying the influence of the...