Jason R ORourke
Overview
Explore the profile of Jason R ORourke including associated specialties, affiliations and a list of published articles.
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9
Citations
1062
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Recent Articles
1.
Millay D, ORourke J, Sutherland L, Bezprozvannaya S, Shelton J, Bassel-Duby R, et al.
Nature
. 2013 Jul;
499(7458):301-5.
PMID: 23868259
Fusion of myoblasts is essential for the formation of multi-nucleated muscle fibres. However, the identity of muscle-specific proteins that directly govern this fusion process in mammals has remained elusive. Here...
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Zhang Z, ORourke J, McManus M, Lewandoski M, Harfe B, Sun X
Dev Biol
. 2011 Jan;
351(2):254-65.
PMID: 21256124
Dicer is an enzyme that processes microRNAs (miRNAs) to their mature forms. As miRNAs were first discovered for their role in the control of developmental timing, we investigated their potential...
4.
Small E, ORourke J, Moresi V, Sutherland L, McAnally J, Gerard R, et al.
Proc Natl Acad Sci U S A
. 2010 Feb;
107(9):4218-23.
PMID: 20142475
microRNAs (miRNAs) play key roles in modulating a variety of cellular processes through repression of mRNA targets. In a screen for miRNAs regulated by myocardin-related transcription factor-A (MRTF-A), a coactivator...
5.
Osborne R, Lin X, Welle S, Sobczak K, ORourke J, Swanson M, et al.
Hum Mol Genet
. 2009 Feb;
18(8):1471-81.
PMID: 19223393
Myotonic dystrophy type 1 (DM1) is an RNA dominant disease in which mutant transcripts containing an expanded CUG repeat (CUG(exp)) cause muscle dysfunction by interfering with biogenesis of other mRNAs....
6.
ORourke J, Swanson M
J Biol Chem
. 2008 Oct;
284(12):7419-23.
PMID: 18957432
Recent mapping of functional sequence elements in the human genome has led to the realization that transcription is pervasive and that noncoding RNAs compose a significant portion of the transcriptome....
7.
Damiani D, Alexander J, ORourke J, McManus M, Jadhav A, Cepko C, et al.
J Neurosci
. 2008 May;
28(19):4878-87.
PMID: 18463241
MicroRNAs (miRNAs) are small, highly conserved molecules that have been shown to regulate the expression of genes by binding to specific target mRNAs. Dicer, an RNase III endonuclease, is essential...
8.
ORourke J, Georges S, Seay H, Tapscott S, McManus M, Goldhamer D, et al.
Dev Biol
. 2007 Oct;
311(2):359-68.
PMID: 17936265
microRNAs (miRNAs) regulate gene expression post-transcriptionally by targeting mRNAs for degradation or by inhibiting translation. Dicer is an RNase III endonuclease which processes miRNA precursors into functional 21-23 nucleotide RNAs...
9.
ORourke J, Swanson M, Harfe B
Birth Defects Res C Embryo Today
. 2006 Jul;
78(2):172-9.
PMID: 16847882
Mammals have evolved a variety of gene regulatory mechanisms to ensure the proper development of tissues during embryonic organogenesis. Recently, microRNAs (miRNAs) have been shown to regulate protein dosage during...