Brian D Harfe
Overview
Explore the profile of Brian D Harfe including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
87
Citations
7673
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Zhu J, Patel R, Trofka A, Harfe B, Mackem S
Dev Cell
. 2022 Aug;
57(17):2048-2062.e4.
PMID: 35977544
Limb patterning by Sonic hedgehog (Shh), via either graded spatial or temporal signal integration, is a paradigm for "morphogen" function, yet how Shh instructs distinct digit identities remains controversial. Here,...
2.
Reibring C, El Shahawy M, Hallberg K, Harfe B, Linde A, Gritli-Linde A
Int J Mol Sci
. 2022 Jun;
23(11).
PMID: 35682776
BMP signaling is crucial for differentiation of secretory ameloblasts, the cells that secrete enamel matrix. However, whether BMP signaling is required for differentiation of maturation-stage ameloblasts (MA), which are instrumental...
3.
Harfe B
Semin Cell Dev Biol
. 2021 Dec;
127:3-9.
PMID: 34865989
The vertebrate notochord plays an essential role in patterning multiple structures during embryonic development. In the early 2000s, descendants of notochord cells were demonstrated to form the entire nucleus pulposus...
4.
El Shahawy M, Reibring C, Hallberg K, Neben C, Marangoni P, Harfe B, et al.
Int J Mol Sci
. 2019 May;
20(9).
PMID: 31072004
Deciphering how signaling pathways interact during development is necessary for understanding the etiopathogenesis of congenital malformations and disease. In several embryonic structures, components of the Hedgehog and retinoic acid pathways,...
5.
Henriques T, Agostinelli E, Hernandez-Clavijo A, Maurya D, Rock J, Harfe B, et al.
J Gen Physiol
. 2019 May;
151(7):954-966.
PMID: 31048412
Glial-like supporting (or sustentacular) cells are important constituents of the olfactory epithelium that are involved in several physiological processes such as production of endocannabinoids, insulin, and ATP and regulation of...
6.
Peck S, McKee K, Tobias J, Malhotra N, Harfe B, Smith L
Sci Rep
. 2017 Sep;
7(1):10504.
PMID: 28874804
Recapitulation of developmental signals represents a promising strategy for treating intervertebral disc degeneration. During development, embryonic notochord-derived cells (NDCs) are the direct progenitors of cells that populate the adult nucleus...
7.
Lawson L, Harfe B
Wiley Interdiscip Rev Dev Biol
. 2017 Jul;
6(6).
PMID: 28719048
The vertebral column consists of repeating units of ossified vertebrae that are adjoined by fibrocartilagenous intervertebral discs. These structures form from the embryonic notochord and somitic mesoderm. In humans, congenital...
8.
El Shahawy M, Reibring C, Neben C, Hallberg K, Marangoni P, Harfe B, et al.
PLoS Genet
. 2017 Jul;
13(7):e1006914.
PMID: 28715412
The interaction between signaling pathways is a central question in the study of organogenesis. Using the developing murine tongue as a model, we uncovered unknown relationships between Sonic hedgehog (SHH)...
9.
Zhang R, Lee C, Lawson L, Svete L, McIntyre L, Harfe B
G3 (Bethesda)
. 2017 Jan;
7(3):851-858.
PMID: 28131983
mRNA variance has been proposed to play key roles in normal development, population fitness, adaptability, and disease. While variance in gene expression levels may be beneficial for certain cellular processes,...
10.
Kaltcheva M, Anderson M, Harfe B, Lewandoski M
Dev Biol
. 2016 Jan;
411(2):266-276.
PMID: 26826495
During vertebrate embryogenesis the interdigital mesenchyme is removed by programmed cell death (PCD), except in species with webbed limbs. Although bone morphogenetic proteins (BMPs) have long been known to be...