Jason P Riley
Overview
Explore the profile of Jason P Riley including associated specialties, affiliations and a list of published articles.
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14
Citations
342
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Recent Articles
1.
Cowden J, Yu F, Banie H, Farahani M, Ling P, Nguyen S, et al.
Ann Rheum Dis
. 2013 Oct;
73(3):600-8.
PMID: 24126456
Objective: The histamine H4 receptor (H4R) has been shown to drive inflammatory responses in models of asthma, colitis and dermatitis, and in these models it appears to affect both innate...
2.
Riley J, Fuchs B, Sjoberg L, Nilsson G, Karlsson L, Dahlen S, et al.
Clin Sci (Lond)
. 2013 Jun;
125(11):533-42.
PMID: 23799245
One feature of allergic asthma, the EAR (early allergic reaction), is not present in the commonly used mouse models. We therefore investigated the mediators involved in EAR in a guinea-pig...
3.
Cowden J, Yu F, Challapalli M, Huang J, Kim S, Fung-Leung W, et al.
Inflamm Res
. 2013 Mar;
62(6):599-607.
PMID: 23532396
Objective: Antagonism of the histamine H4 receptor (H4R) has been shown to be anti-inflammatory in a number of preclinical disease models, however the exact mechanisms behind this are still being...
4.
Eccles W, Blevitt J, Booker J, Chrovian C, Crawford S, de Leon A, et al.
Bioorg Med Chem Lett
. 2012 Dec;
23(3):811-5.
PMID: 23260350
Leukotrienes (LT's) are known to play a physiological role in inflammatory immune response. Leukotriene A(4) hydrolase (LTA(4)H) is a cystolic enzyme that stereospecifically catalyzes the transformation of LTA(4) to LTB(4)....
5.
Tanis V, Bacani G, Blevitt J, Chrovian C, Crawford S, De Leon A, et al.
Bioorg Med Chem Lett
. 2012 Nov;
22(24):7504-11.
PMID: 23127888
Previously, benzthiazole containing LTA(4)H inhibitors were discovered that were potent (1-3), but were associated with the potential for a hERG liability. Utilizing medicinal chemistry first principles (e.g., introducing rigidity, lowering...
6.
Cowden J, Riley J, Ma J, Thurmond R, Dunford P
Respir Res
. 2010 Jun;
11:86.
PMID: 20573261
Background: Airway remodeling and dysfunction are characteristic features of asthma thought to be caused by aberrant production of Th2 cytokines. Histamine H4 receptor (H4R) perturbation has previously been shown to...
7.
Rao N, Riley J, Banie H, Xue X, Sun B, Crawford S, et al.
Am J Respir Crit Care Med
. 2010 Jan;
181(9):899-907.
PMID: 20110560
Rationale: Allergic asthma is characterized by reversible airway obstruction, lung inflammation, and airway hyperresponsiveness (AHR). Previous studies using leukotriene B(4) (LTB(4)) receptor 1-deficient mice and adoptive transfer experiments have suggested...
8.
Grice C, Tays K, Savall B, Wei J, Butler C, Axe F, et al.
J Med Chem
. 2008 Jul;
51(14):4150-69.
PMID: 18588282
LTA 4H is a ubiquitously distributed 69 kDa zinc-containing cytosolic enzyme with both hydrolase and aminopeptidase activity. As a hydrolase, LTA 4H stereospecifically catalyzes the transformation of the unstable epoxide...
9.
Crawford S, Belajic D, Wei J, Riley J, Dunford P, Bembenek S, et al.
Mol Cancer Ther
. 2008 Mar;
7(3):492-9.
PMID: 18347137
B-RAF mutations have been identified in the majority of melanoma and a large fraction of colorectal and papillary thyroid carcinoma. Drug discovery efforts targeting mutated B-RAF have yielded several interesting...
10.
Rao N, Dunford P, Xue X, Jiang X, Lundeen K, Coles F, et al.
J Pharmacol Exp Ther
. 2007 Mar;
321(3):1154-60.
PMID: 17371808
Leukotriene A(4) hydrolase (LTA(4)H) catalyzes production of the proinflammatory lipid mediator, leukotriene (LT) B(4), which is implicated in a number of inflammatory diseases. We have identified a potent and selective...