Paul J Dunford
Overview
Explore the profile of Paul J Dunford including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
22
Citations
807
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Manthey C, Moore B, Chen Y, Loza M, Yao X, Liu H, et al.
PLoS One
. 2019 Nov;
14(11):e0223918.
PMID: 31710624
Background & Aims: Originally believed to be primarily a disorder of T-cell signaling, evidence shows that macrophage-lineage cells also contribute to the pathogenesis of Crohn's disease (CD). Colony stimulating factor-1...
2.
Boyle D, DePrimo S, Calderon C, Chen D, Dunford P, Barchuk W, et al.
Inflamm Res
. 2019 Feb;
68(4):261-274.
PMID: 30739130
Objective/design: In a double-blind, placebo-controlled, multiple-dose study, we assessed the molecular mechanism of action of the selective histamine-4-receptor antagonist toreforant. Patients/treatment: Patients with active rheumatoid arthritis (RA) despite methotrexate were...
3.
Thurmond R, Venable J, Savall B, La D, Snook S, Dunford P, et al.
Handb Exp Pharmacol
. 2017 Feb;
241:301-320.
PMID: 28233185
The discovery of the histamine H receptor (HR) provided a new avenue for the exploration of the physiological role of histamine, as well as providing a new drug target for...
4.
Kollmeier A, Francke K, Chen B, Dunford P, Greenspan A, Xia Y, et al.
J Pharmacol Exp Ther
. 2014 May;
350(1):181-7.
PMID: 24817035
The histamine H4 receptor (H4R) is a promising target for the treatment of pruritus. A clinical study was conducted to evaluate the safety and efficacy of the H4R antagonist, JNJ...
5.
Thurmond R, Chen B, Dunford P, Greenspan A, Karlsson L, La D, et al.
J Pharmacol Exp Ther
. 2014 Feb;
349(2):176-84.
PMID: 24549371
The histamine H4 receptor (H(4)R) has been shown to have preclinical involvement in both inflammatory and pruritic responses. JNJ-39758979 [(R)-4-(3-amino-pyrrolidin-1-yl)-6-isopropyl-pyrimidin-2-ylamine] is a potent and selective H(4)R antagonist with a Ki...
6.
Savall B, Chavez F, Tays K, Dunford P, Cowden J, Hack M, et al.
J Med Chem
. 2014 Feb;
57(6):2429-39.
PMID: 24495018
This report discloses the discovery and SAR of a series of 6-alkyl-2-aminopyrimidine derived histamine H4 antagonists that led to the development of JNJ 39758979, which has been studied in phase...
7.
Cowden J, Yu F, Banie H, Farahani M, Ling P, Nguyen S, et al.
Ann Rheum Dis
. 2013 Oct;
73(3):600-8.
PMID: 24126456
Objective: The histamine H4 receptor (H4R) has been shown to drive inflammatory responses in models of asthma, colitis and dermatitis, and in these models it appears to affect both innate...
8.
Cowden J, Yu F, Challapalli M, Huang J, Kim S, Fung-Leung W, et al.
Inflamm Res
. 2013 Mar;
62(6):599-607.
PMID: 23532396
Objective: Antagonism of the histamine H4 receptor (H4R) has been shown to be anti-inflammatory in a number of preclinical disease models, however the exact mechanisms behind this are still being...
9.
Dunford P, Holgate S
Adv Exp Med Biol
. 2011 May;
709:53-66.
PMID: 21618887
Histamine is a ubiquitous inflammatory mediator intimately associated with the pathology of allergy. Traditional antihistamines, targeting the histamine H1 receptor, have failed to demonstrate a significant role for histamine in...
10.
Cowden J, Riley J, Ma J, Thurmond R, Dunford P
Respir Res
. 2010 Jun;
11:86.
PMID: 20573261
Background: Airway remodeling and dysfunction are characteristic features of asthma thought to be caused by aberrant production of Th2 cytokines. Histamine H4 receptor (H4R) perturbation has previously been shown to...