Jason M Link
Overview
Explore the profile of Jason M Link including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
159
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Recent Articles
1.
Tessier J, Grygoryev D, Chow-Castro M, Ekstrom T, Manalo E, Lee S, et al.
STAR Protoc
. 2025 Mar;
6(1):103672.
PMID: 40048424
Pancreatic ductal adenocarcinoma (PDAC) exhibits extensive inter- and intratumoral heterogeneity, along with a significant stromal component. This protocol outlines steps to generate patient-derived xenografts (PDXs), isolate and enrich human PDAC...
2.
Link J, Eng J, Pelz C, MacPherson-Hawthorne K, Worth P, Sivagnanam S, et al.
Nat Cancer
. 2025 Jan;
6(1):123-144.
PMID: 39789181
Patients with metastatic pancreatic ductal adenocarcinoma survive longer if disease spreads to the lung but not the liver. Here we generated overlapping, multi-omic datasets to identify molecular and cellular features...
3.
Grygoryev D, Ekstrom T, Manalo E, Link J, Alshaikh A, Keith D, et al.
Heliyon
. 2024 Mar;
10(5):e27221.
PMID: 38463758
Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly intratumorally heterogeneous disease that includes several subtypes and is highly plastic. Effective gene delivery to all PDAC cells is essential for modulating...
4.
Ghukasyan R, Liang K, Chau K, Li L, Chan C, Abt E, et al.
Clin Cancer Res
. 2023 May;
29(16):3130-3141.
PMID: 37195712
Purpose: Stimulator of interferon genes (STING) agonists are currently in development for treatment of solid tumors, including pancreatic ductal adenocarcinoma (PDAC). Response rates to STING agonists alone have been promising...
5.
T-cell Dysfunction upon Expression of MYC with Altered Phosphorylation at Threonine 58 and Serine 62
Daniel C, Pelz C, Wang X, Munks M, Ko A, Murugan D, et al.
Mol Cancer Res
. 2022 Apr;
20(7):1151-1165.
PMID: 35380701
Implications: Dysregulation of phosphorylation at conserved T58 and S62 residues of MYC differentially affects T-cell development and lymphomagenesis.
6.
Abt E, Le T, Dann A, Capri J, Poddar S, Lok V, et al.
Cell Rep
. 2022 Jan;
38(2):110236.
PMID: 35021095
We determine that type I interferon (IFN) response biomarkers are enriched in a subset of pancreatic ductal adenocarcinoma (PDAC) tumors; however, actionable vulnerabilities associated with IFN signaling have not been...
7.
Link J, Liudahl S, Betts C, Sivagnanam S, Leis K, McDonnell M, et al.
JCO Precis Oncol
. 2021 May;
5.
PMID: 34036232
No abstract available.
8.
Link J, Hurlin P
Biochim Biophys Acta
. 2014 Apr;
1849(5):554-62.
PMID: 24731854
The MYC family of proteins plays essential roles in embryonic development and in oncogenesis. Efforts over the past 30 years to define the transcriptional activities of MYC and how MYC...
9.
10.
Link J, Ota S, Zhou Z, Daniel C, Sears R, Hurlin P
Proc Natl Acad Sci U S A
. 2012 Nov;
109(48):19685-90.
PMID: 23150551
Mnt (Max's next tango) is a Max-interacting transcriptional repressor that can antagonize both the proproliferative and proapoptotic functions of Myc in vitro. To ascertain the physiologically relevant functions of Mnt...