Jason J Kwon
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Explore the profile of Jason J Kwon including associated specialties, affiliations and a list of published articles.
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15
Citations
365
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Recent Articles
1.
Hwang J, Likasitwatanakul P, Deshmukh S, Wu S, Kwon J, Toye E, et al.
Clin Cancer Res
. 2025 Jan;
31(5):936-948.
PMID: 39745364
Purpose: Around 10% to 15% of prostate cancers harbor recurrent aberrations in the Forkhead Box A1 gene, FOXA1, whereby the alteration type and the effect on the forkhead (FKH) domain...
2.
Kwon J, Dilly J, Liu S, Kim E, Bian Y, Dharmaiah S, et al.
bioRxiv
. 2024 Nov;
PMID: 39484452
To dissect variant-function relationships in the KRAS oncoprotein, we performed deep mutational scanning (DMS) screens for both wild-type and KRAS mutant alleles. We defined the spectrum of oncogenic potential for...
3.
Kwon J, Pan J, Gonzalez G, Hahn W, Zitnik M
Cell Syst
. 2024 May;
15(6):488-496.
PMID: 38810640
As words can have multiple meanings that depend on sentence context, genes can have various functions that depend on the surrounding biological system. This pleiotropic nature of gene function is...
4.
Bian Y, Kwon J, Liu C, Margiotta E, Shekhar M, Gould A
Front Mol Biosci
. 2023 Mar;
10:1163536.
PMID: 36994428
High-throughput screening (HTS) methods enable the empirical evaluation of a large scale of compounds and can be augmented by virtual screening (VS) techniques to save time and money by using...
5.
So J, Mabe N, Englinger B, Chow K, Moyer S, Yerrum S, et al.
JCI Insight
. 2022 Aug;
7(19).
PMID: 36040810
Collateral lethality occurs when loss of a gene/protein renders cancer cells dependent on its remaining paralog. Combining genome-scale CRISPR/Cas9 loss-of-function screens with RNA sequencing in over 900 cancer cell lines,...
6.
Kwon J, Hajian B, Bian Y, Young L, Amor A, Fuller J, et al.
Nature
. 2022 Jul;
609(7926):408-415.
PMID: 35831509
Receptor tyrosine kinase (RTK)-RAS signalling through the downstream mitogen-activated protein kinase (MAPK) cascade regulates cell proliferation and survival. The SHOC2-MRAS-PP1C holophosphatase complex functions as a key regulator of RTK-RAS signalling...
7.
Pan J, Kwon J, Talamas J, Borah A, Vazquez F, Boehm J, et al.
Cell Syst
. 2022 Jan;
13(4):286-303.e10.
PMID: 35085500
In high-throughput functional genomic screens, each gene product is commonly assumed to exhibit a singular biological function within a defined protein complex or pathway. In practice, a single gene perturbation...
8.
Dey S, Udari L, RiveraHernandez P, Kwon J, Willis B, Easler J, et al.
JCI Insight
. 2021 Aug;
6(19).
PMID: 34464354
MicroRNA-29 (miR-29) is a critical regulator of fibroinflammatory processes in human diseases. In this study, we found a decrease in miR-29a in experimental and human chronic pancreatitis, leading us to...
9.
Kwon J, Hahn W
Mol Cell Biol
. 2021 Feb;
41(4).
PMID: 33526449
SHOC2 is a prototypical leucine-rich repeat protein that promotes downstream receptor tyrosine kinase (RTK)/RAS signaling and plays important roles in several cellular and developmental processes. Gain-of-function germ line mutations of...
10.
Dey S, Kwon J, Liu S, Hodge G, Taleb S, Zimmers T, et al.
Mol Cancer Res
. 2019 Oct;
18(2):311-323.
PMID: 31662451
Pancreatic ductal adenocarcinoma (PDAC) is an intractable cancer with a dismal prognosis. miR-29a is commonly downregulated in PDAC; however, mechanisms for its loss and role still remain unclear. Here, we...