Jason E DeRouchey
Overview
Explore the profile of Jason E DeRouchey including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
133
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Recent Articles
1.
Ahmed A, Gallegos Z, Dinar M, Sullivan P, DeRouchey J, Patel S, et al.
J Biomed Mater Res B Appl Biomater
. 2025 Feb;
113(2):e35537.
PMID: 39907118
Traumatic spinal cord injury (SCI) presents a significant medical challenge due to its intricate nature and treatment complexities. SCI can cause physical impairments by affecting neural and motor functions as...
2.
Uddin M, Dinar M, Schrass L, Pack D, DeRouchey J
Biomacromolecules
. 2024 Dec;
26(1):178-189.
PMID: 39690700
Polyethylenimine (PEI) is a widely used cationic polymer for nonviral gene delivery, often modified to enhance transfection efficiency and reduce cytotoxicity. This study investigates how acetylation, succinylation (acPEI and zPEI),...
3.
Oikeh E, Ziebarth J, Dinar M, Kirchhoff D, Aronova A, Dziubla T, et al.
J Phys Chem B
. 2024 Apr;
128(14):3329-3339.
PMID: 38557033
In nature, DNA exists primarily in a highly compacted form. The compaction of DNA in vivo is mediated by cationic proteins: histones in somatic nuclei and protamines in sperm chromatin....
4.
Mitchell R, Kriger S, Fenton A, Havrylyuk D, Pandeya A, Sun Y, et al.
RSC Chem Biol
. 2023 May;
4(5):344-353.
PMID: 37181632
Ruthenium complexes are often investigated as potential replacements for platinum-based chemotherapeutics in hopes of identifying systems with improved tolerability and reduced susceptibility to cellular resistance mechanisms. Inspired by phenanthriplatin, a...
5.
Shadman H, Gallops C, Ziebarth J, DeRouchey J, Wang Y
ACS Omega
. 2022 Nov;
7(46):42083-42095.
PMID: 36440140
Protamines are arginine-rich proteins that condense DNA in sperm. Despite their importance in reproduction, information on protamine structure is scarce. We, therefore, used molecular dynamics to examine the structures of...
6.
Patel S, Michael F, Khan M, Duggan B, Wyse S, Darby D, et al.
Mitochondrion
. 2022 Apr;
64:145-155.
PMID: 35398305
We developed a thermal-gelling, erodible hydrogel system for localized delivery of viable mitochondria in vivo, as well as labeled transplanted mitochondria with specific dyes and/or genetically modified mitochondria tagged with...
7.
Uddin N, Warriner L, Pack D, DeRouchey J
Mol Pharm
. 2021 Aug;
18(9):3452-3463.
PMID: 34387498
Gene therapy aims to treat patients by altering or controlling gene expression. The field of gene therapy has had increasing success in recent years primarily using viral-based approaches; however, there...
8.
Saintilnord W, Tenlep S, Preston J, Duregon E, DeRouchey J, Unrine J, et al.
Toxicol Sci
. 2021 Jan;
180(2):262-276.
PMID: 33483743
Cadmium exposure is ubiquitous and has been linked to diseases including cancers and reproductive defects. Since cadmium is nonmutagenic, it is thought to exert its gene dysregulatory effects through epigenetic...
9.
Powell C, Kirchoff D, DeRouchey J, Moseley H
BMC Genomics
. 2020 Apr;
21(1):277.
PMID: 32245406
Background: Spermatogenesis is the process by which germ cells develop into spermatozoa in the testis. Sperm protamines are small, arginine-rich nuclear proteins which replace somatic histones during spermatogenesis, allowing a...
10.
Fu X, Song Y, Masud A, Nuti K, DeRouchey J, Richards C
Anal Bioanal Chem
. 2020 Mar;
412(11):2589-2597.
PMID: 32146499
Extracellular vesicles (EVs) and cell-derived vesicles (CDVs), generated by fragmenting cellular membranes, have both been explored as therapeutic delivery vehicles. Surface proteins on these vesicles are of great importance as...