Daniel W Pack
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Explore the profile of Daniel W Pack including associated specialties, affiliations and a list of published articles.
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61
Citations
1652
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Recent Articles
1.
Uddin M, Dinar M, Schrass L, Pack D, DeRouchey J
Biomacromolecules
. 2024 Dec;
26(1):178-189.
PMID: 39690700
Polyethylenimine (PEI) is a widely used cationic polymer for nonviral gene delivery, often modified to enhance transfection efficiency and reduce cytotoxicity. This study investigates how acetylation, succinylation (acPEI and zPEI),...
2.
Mott L, Hancock M, Grulke E, Pack D
ACS Appl Bio Mater
. 2023 Jul;
6(8):3166-3175.
PMID: 37493016
Various diseases, including cancers and inflammatory diseases, are characterized by a disruption of redox homeostasis, suggesting the need for synergistic treatments involving co-delivery of gene therapies and free radical scavengers....
3.
Uddin N, Warriner L, Pack D, DeRouchey J
Mol Pharm
. 2021 Aug;
18(9):3452-3463.
PMID: 34387498
Gene therapy aims to treat patients by altering or controlling gene expression. The field of gene therapy has had increasing success in recent years primarily using viral-based approaches; however, there...
4.
Nardo D, Akers C, Cheung N, Isom C, Spaude J, Pack D, et al.
RSC Adv
. 2021 Aug;
11(40):24752-24761.
PMID: 34354826
Cyanuric chloride has been utilized in the development of new synthetic lipid compounds using two differing schemes. The resulting lipids, presented in this manuscript, were characterized and evaluated for their...
5.
Warriner L, Duke 3rd J, Pack D, DeRouchey J
Biomacromolecules
. 2018 Oct;
19(11):4348-4357.
PMID: 30354068
Polymeric materials provide particularly attractive scaffolds for the creation of supramolecular bioconjugates for the delivery of nucleic acids but typically lack the efficiency and biocompatibility to be clinically relevant. To...
6.
Mott L, Su K, Pack D
Cancer Gene Ther
. 2018 Mar;
25(3-4):84-91.
PMID: 29511313
Basal-like breast cancer (BLBC) is a malignant carcinoma with aggressive motility and rapid growth. Accounting for 15% of breast cancers, BLBC often exhibits a poor prognosis and tends to metastasize...
7.
Mottaghitalab F, Rastegari A, Farokhi M, Dinarvand R, Hosseinkhani H, Ou K, et al.
Int J Pharm
. 2017 Apr;
524(1-2):312-329.
PMID: 28385649
Small interfering RNA (siRNA) has established its reputation in the field of tissue engineering owing to its ability to silence the proteins that inhibit tissue regeneration. siRNA is capable of...
8.
Lazebnik M, Pack D
J Control Release
. 2017 Jan;
247:19-27.
PMID: 28043862
Design of safe and effective synthetic nucleic acid delivery vectors such as polycation/DNA or polycation/siRNA complexes (polyplexes) will be facilitated by quantitative understanding of the mechanisms by which such materials...
9.
Lazebnik M, Keswani R, Pack D
Pharm Res
. 2016 Sep;
33(12):2999-3011.
PMID: 27585903
Purpose: siRNA may be delivered as electrostatic complexes with cationic lipids (lipoplexes) or polycations (polyplexes). The purpose of this project was to determine the effect of cellular internalization mechanism(s) on...
10.
Ford Versypt A, Arendt P, Pack D, Braatz R
PLoS One
. 2015 Aug;
10(8):e0135506.
PMID: 26284787
A mathematical reaction-diffusion model is defined to describe the gradual decomposition of polymer microspheres composed of poly(D,L-lactic-co-glycolic acid) (PLGA) that are used for pharmaceutical drug delivery over extended periods of...