Jason De Melo
Overview
Explore the profile of Jason De Melo including associated specialties, affiliations and a list of published articles.
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16
Citations
510
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Recent Articles
1.
Hickman K, Hariharan S, De Melo J, Ylanko J, Lustig L, Penn L, et al.
Cytometry A
. 2019 Nov;
97(4):363-377.
PMID: 31774248
Short half-life proteins regulate many essential processes, including cell cycle, transcription, and apoptosis. However, few well-characterized protein-turnover pathways have been identified because traditional methods to measure protein half-life are time...
2.
Lourenco C, Kalkat M, Houlahan K, De Melo J, Longo J, Done S, et al.
Dis Model Mech
. 2019 Jul;
12(7).
PMID: 31350286
The potent MYC oncoprotein is deregulated in many human cancers, including breast carcinoma, and is associated with aggressive disease. To understand the mechanisms and vulnerabilities of MYC-driven breast cancer, we...
3.
Dingar D, Tu W, Resetca D, Lourenco C, Tamachi A, De Melo J, et al.
Nat Commun
. 2018 Aug;
9(1):3502.
PMID: 30158517
The c-MYC (MYC) oncoprotein is deregulated in over 50% of cancers, yet regulatory mechanisms controlling MYC remain unclear. To this end, we interrogated the MYC interactome using BioID mass spectrometry...
4.
Gu Y, Chow M, Kapoor A, Mei W, Jiang Y, Yan J, et al.
Transl Oncol
. 2018 Jul;
11(4):1012-1022.
PMID: 29966864
Butyrylcholinesterase (BChE) is a plasma enzyme that hydrolyzes ghrelin and bioactive esters, suggesting a role in modulating metabolism. Serum BChE is reduced in cancer patients. In prostate cancer (PC), the...
5.
Kalkat M, De Melo J, Hickman K, Lourenco C, Redel C, Resetca D, et al.
Genes (Basel)
. 2017 Jun;
8(6).
PMID: 28587062
MYC regulates a complex biological program by transcriptionally activating and repressing its numerous target genes. As such, MYC is a master regulator of many processes, including cell cycle entry, ribosome...
6.
Wong N, Gu Y, Kapoor A, Lin X, Ojo D, Wei F, et al.
Oncotarget
. 2017 Feb;
8(12):19218-19235.
PMID: 28186973
Although the FAM84B gene lies within chromosome 8q24, a locus frequently altered in prostate cancer (PC), its alteration during prostate tumorigenesis has not been well studied. We report here FAM84B...
7.
Xie Y, Shen Y, Kapoor A, Ojo D, Wei F, De Melo J, et al.
Data Brief
. 2016 Mar;
6:811-6.
PMID: 26937452
We have recently reported that CYB5D2 plays a role in suppression of cervical cancer tumorigenesis, "CYB5D2 displays tumor suppression activities towards cervical cancer" [1]. We provide the accompany data here...
8.
Yan J, Ojo D, Kapoor A, Lin X, Pinthus J, Aziz T, et al.
Cancer Res
. 2016 Jan;
76(6):1603-14.
PMID: 26795349
Prostate cancer metastasis is the main cause of disease-related mortality. Elucidating the mechanisms underlying prostate cancer metastasis is critical for effective therapeutic intervention. In this study, we performed gene-expression profiling...
9.
Xie Y, Shen Y, Kapoor A, Ojo D, Wei F, De Melo J, et al.
Biochim Biophys Acta
. 2015 Dec;
1862(4):556-565.
PMID: 26692170
Cervical cancer is caused by infections with human papillomaviruses (HPV) and genetic alternations in the cervical epithelium. While the former is well studied, the latter remains unclear. We report here...
10.
De Melo J, Tang D
PLoS One
. 2015 May;
10(5):e0127546.
PMID: 25992689
SIPL1 (Sharpin) or Sharpin plays a role in tumorigenesis. However, its involvement in breast cancer tumorigenesis remains largely unknown. To investigate this issue, we have systemically analyzed SIPL1 gene amplification...