Jason De Melo
Overview
Explore the profile of Jason De Melo including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
510
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0
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Recent Articles
11.
Hill B, De Melo J, Yan J, Kapoor A, He L, Cutz J, et al.
Oncotarget
. 2014 Oct;
5(17):7406-19.
PMID: 25277181
Despite the recent progress in our understanding of clear cell renal cell carcinomas (ccRCCs), the etiology of ccRCC remains unclear. We reported here a prevailing reduction of the raf kinase...
12.
De Melo J, Lin X, He L, Wei F, Major P, Tang D
Cell Signal
. 2014 Aug;
26(12):2749-56.
PMID: 25152374
PTEN is post-translationally modified by ubiquitin via association with multiple E3 ubiquitin ligases, including NEDD4-1, XIAP, and WWP2. Despite the rapid progress made in researching the impact of ubiquitination on...
13.
SIPL1 enhances the proliferation, attachment, and migration of CHO cells by inhibiting PTEN function
De Melo J, Wu V, He L, Yan J, Tang D
Int J Mol Med
. 2014 Jul;
34(3):835-41.
PMID: 25018115
The PTEN tumour suppressor plays critical roles in inhibiting cell proliferation, adhesion and migration through downregulation of the PI3K-AKT pathway. SIPL1 is a novel PTEN‑negative regulator (PTEN-NR) that contributes to...
14.
Wong N, Yan J, Ojo D, De Melo J, Cutz J, Tang D
Cancer Invest
. 2014 Jun;
32(7):330-8.
PMID: 24884829
Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29...
15.
Wong N, De Melo J, Tang D
Int J Cell Biol
. 2013 Mar;
2013:242513.
PMID: 23476652
Aerobic glycolysis is the dominant metabolic pathway utilized by cancer cells, owing to its ability to divert glucose metabolites from ATP production towards the synthesis of cellular building blocks (nucleotides,...
16.
Fan C, He L, Kapoor A, Rybak A, De Melo J, Cutz J, et al.
Mol Cancer
. 2009 Nov;
8:98.
PMID: 19903340
Background: PTEN is the second most mutated tumor suppressor gene other than p53. It suppresses tumorigenesis by dephosphorylating phosphatidylinositol (3,4,5)-triphosphate (PIP3) to phosphatidylinositol (4,5)-biphosphate (PIP2), thereby directly inhibiting phosphatidylinositol 3...