Jason D Fontenot
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Explore the profile of Jason D Fontenot including associated specialties, affiliations and a list of published articles.
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7514
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Recent Articles
11.
Enyedy I, Powell N, Caravella J, van Vloten K, Chao J, Banerjee D, et al.
Bioorg Med Chem Lett
. 2016 Apr;
26(10):2459-2463.
PMID: 27080181
RORγ plays a critical role in controlling a pro-inflammatory gene expression program in several lymphocyte lineages including T cells, γδ T cells, and innate lymphoid cells. RORγ-mediated inflammation has been...
12.
Huss D, Pellerin A, Collette B, Kannan A, Peng L, Datta A, et al.
Immunology
. 2016 Mar;
148(3):276-86.
PMID: 27012310
Interleukin-2 (IL-2) is a critical regulator of immune homeostasis through its non-redundant role in regulatory T (Treg) cell biology. There is major interest in therapeutic modulation of the IL-2 pathway...
13.
Banerjee D, Zhao L, Wu L, Palanichamy A, Ergun A, Peng L, et al.
Immunology
. 2015 Dec;
147(4):399-413.
PMID: 26694902
Retinoic acid receptor-related orphan nuclear receptor γ (RORγ) orchestrates a pro-inflammatory gene expression programme in multiple lymphocyte lineages including T helper type 17 (Th17) cells, γδ T cells, innate lymphoid...
14.
Gillard G, Collette B, Anderson J, Chao J, Scannevin R, Huss D, et al.
J Neuroimmunol
. 2015 May;
283:74-85.
PMID: 26004161
Fumarate-containing pharmaceuticals are potent therapeutic agents that influence multiple cellular pathways. Despite proven clinical efficacy, there is a significant lack of data that directly defines the molecular mechanisms of action...
15.
Huss D, Mehta D, Sharma A, You X, Riester K, Sheridan J, et al.
J Immunol
. 2014 Nov;
194(1):84-92.
PMID: 25416807
Regulatory T cells (Tregs) mediate immune tolerance to self and depend on IL-2 for homeostasis. Treg deficiency, dysfunction, and instability are implicated in the pathogenesis of numerous autoimmune diseases. There...
16.
Scott-Browne J, Shafiani S, Tucker-Heard G, Ishida-Tsubota K, Fontenot J, Rudensky A, et al.
J Exp Med
. 2007 Aug;
204(9):2159-69.
PMID: 17709423
Mycobacterium tuberculosis (Mtb) frequently establishes persistent infections that may be facilitated by mechanisms that dampen immunity. T regulatory (T reg) cells, a subset of CD4(+) T cells that are essential...
17.
Sather B, Treuting P, Perdue N, Miazgowicz M, Fontenot J, Rudensky A, et al.
J Exp Med
. 2007 Jun;
204(6):1335-47.
PMID: 17548521
CD4(+)Foxp3(+) regulatory T cells (T reg) are essential for maintaining self-tolerance, but their functional mechanisms and sites of action in vivo are poorly defined. We examined the homing receptor expression...
18.
Gavin M, Rasmussen J, Fontenot J, Vasta V, Manganiello V, Beavo J, et al.
Nature
. 2007 Jan;
445(7129):771-5.
PMID: 17220874
Regulatory CD4+ T cells (Tr cells), the development of which is critically dependent on X-linked transcription factor Foxp3 (forkhead box P3), prevent self-destructive immune responses. Despite its important role, molecular...
19.
Uhlig H, Coombes J, Mottet C, Izcue A, Thompson C, Fanger A, et al.
J Immunol
. 2006 Oct;
177(9):5852-60.
PMID: 17056509
CD4+CD25+ regulatory T cells can prevent and resolve intestinal inflammation in the murine T cell transfer model of colitis. Using Foxp3 as a marker of regulatory T cell activity, we...
20.
Hsieh C, Zheng Y, Liang Y, Fontenot J, Rudensky A
Nat Immunol
. 2006 Mar;
7(4):401-10.
PMID: 16532000
The relationship between the T cell receptor (TCR) repertoires used by self-reactive transcription factor Foxp3-positive (Foxp3(+)) CD4(+) regulatory T cells (T(reg) cells) and nonregulatory T cells with autoimmune potential is...