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Ellen Cahir-McFarland

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Citations 1911
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Recent Articles
1.
Deffner M, Schneider-Hohendorf T, Schulte-Mecklenbeck A, Falk S, Lu I, Ostkamp P, et al.
Cell Rep Med . 2024 Jun; 5(7):101622. PMID: 38917802
Progressive multifocal leukoencephalopathy (PML) has been associated with different forms of immune compromise. This study analyzes the chemokine signals and attracted immune cells in cerebrospinal fluid (CSF) during PML to...
2.
Ho P, Cahir-McFarland E, Fontenot J, Lodie T, Nada A, Tang Q, et al.
Sci Transl Med . 2024 Mar; 16(738):eadm8859. PMID: 38478632
Engineered regulatory T (T) cells have emerged as precision therapeutics aimed at inducing immune tolerance while reducing the risks associated with generalized immunosuppression. This Viewpoint highlights the opportunities and challenges...
3.
Grover A, Sankaranarayanan S, Mathur V, Suri P, Qiu H, Andrews-Zwilling Y, et al.
Invest Ophthalmol Vis Sci . 2023 Feb; 64(2):3. PMID: 36729444
Purpose: C1q and the classical complement cascade are key regulators of synaptic pruning, and their aberrant activation has been implicated in neurodegenerative ophthalmic diseases including geographic atrophy and glaucoma. The...
4.
Elliott C, Momayyezsiahkal P, Arnold D, Liu D, Ke J, Zhu L, et al.
Brain Commun . 2021 Sep; 3(3):fcab176. PMID: 34557664
Normal-appearing white matter is far from normal in multiple sclerosis; little is known about the precise pathology or spatial pattern of this alteration and its relation to subsequent lesion formation....
5.
Pellerin K, Rubino S, Burns J, Smith B, Mccarl C, Zhu J, et al.
Brain . 2021 Jun; 144(8):2361-2374. PMID: 34145876
Autoantibodies are a hallmark of numerous neurological disorders, including multiple sclerosis, autoimmune encephalitides and neuromyelitis optica. Whilst well understood in peripheral myeloid cells, the pathophysiological significance of autoantibody-induced Fc receptor...
6.
Linden J, Telesford K, Shetty S, Winokour P, Haigh S, Cahir-McFarland E, et al.
Antibodies (Basel) . 2019 Sep; 7(4). PMID: 31544887
The pore-forming epsilon toxin (ETX) produced by is among the most lethal bacterial toxins known. Sensitive antibody-based reagents are needed to detect toxin, distinguish mechanisms of cell death, and prevent...
7.
McAvoy K, Rajamohamed Sait H, Marsh G, Peterson M, Reynolds T, Gagnon J, et al.
PLoS One . 2019 Aug; 14(8):e0220125. PMID: 31408457
BIN1 is the most important risk locus for Late Onset Alzheimer's Disease (LOAD), after ApoE. BIN1 AD-associated SNPs correlate with Tau deposition as well as with brain atrophy. Furthermore, the...
8.
Crotti A, Sait H, McAvoy K, Estrada K, Ergun A, Szak S, et al.
Sci Rep . 2019 Jul; 9(1):9477. PMID: 31263146
Despite Bridging INtegrator 1 (BIN1) being the second most statistically-significant locus associated to Late Onset Alzheimer's Disease, its role in disease pathogenesis remains to be clarified. As reports suggest a...
9.
Wang L, Shen H, Nobre L, Ersing I, Paulo J, Trudeau S, et al.
Cell Metab . 2019 Jul; 30(3):539-555.e11. PMID: 31257153
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely unknown. To gain insights, primary human...
10.
Chadli L, Sotthewes B, Li K, Andersen S, Cahir-McFarland E, Cheung M, et al.
Sci Rep . 2019 Mar; 9(1):4521. PMID: 30872777
Systemic sclerosis (SSc or scleroderma) is an auto-immune disease characterized by skin fibrosis. While primary cells from patients are considered as a unique resource to better understand human disease biology,...