Jason C OConnor
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Explore the profile of Jason C OConnor including associated specialties, affiliations and a list of published articles.
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62
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5238
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Recent Articles
1.
Saliba A, Debnath S, Tamayo I, Lee H, Ragi N, Das F, et al.
JCI Insight
. 2025 Feb;
PMID: 39946208
Kidney dysfunction often leads to neurological impairment, yet the complex kidney-brain relationship remains elusive. We employed spatial and bulk metabolomics to investigate a mouse model of rapid kidney failure induced...
2.
Mithaiwala M, Phillips N, Nguyen D, Beehler M, Ballard H, Vincent A, et al.
Addict Biol
. 2024 Nov;
29(11):e70000.
PMID: 39558659
Individuals with a family history of alcohol or other substance use disorders (FH+) are at increased risk for developing alcohol and other substance use disorders (AUD/SUD) compared to individuals with...
3.
de Miranda A, de Brito Toscano E, OConnor J, Teixeira A
Expert Opin Ther Targets
. 2024 Jun;
28(5):401-418.
PMID: 38871633
Introduction: Inflammasome complexes, especially NLRP3, have gained great attention as a potential therapeutic target in mood disorders. NLRP3 triggers a caspase 1-dependent release of the inflammatory cytokines IL-1β and IL-18,...
4.
Saliba A, Debnath S, Tamayo I, Tumova J, Maddox M, Singh P, et al.
bioRxiv
. 2024 May;
PMID: 38766008
Kidney dysfunction often leads to neurological impairment, yet the complex kidney-brain relationship remains elusive. We employed spatial and bulk metabolomics to investigate a mouse model of rapid kidney failure induced...
5.
Ge G, Sivasubramanian B, Geng B, Zhao S, Zhou Q, Huang G, et al.
Gene Ther
. 2024 Apr;
31(5-6):324-334.
PMID: 38627469
Glial cell line-derived neurotrophic factor (GDNF) protects dopaminergic neurons in various models of Parkinson's disease (PD). Cell-based GDNF gene delivery mitigates neurodegeneration and improves both motor and non-motor functions in...
6.
Robbins R, Cortes T, OConnor J, Jiwani R, Serra M
JMIR Res Protoc
. 2023 Nov;
12:e52199.
PMID: 37910166
Background: Fatigue is a strong predictor of negative health outcomes in older adults. Kynurenine, a metabolite of tryptophan, is strongly associated with fatigue. Reductions in fatigue are observed with exercise;...
7.
Maganin A, Souza G, Fonseca M, Lopes A, Guimaraes R, Dagostin A, et al.
J Clin Invest
. 2022 Oct;
132(23).
PMID: 36227694
Neuropathic pain is one of the most important clinical consequences of injury to the somatosensory system. Nevertheless, the critical pathophysiological mechanisms involved in neuropathic pain development are poorly understood. In...
8.
Serra M, Hafer-Macko C, Robbins R, OConnor J, Ryan A
Arch Phys Med Rehabil
. 2022 Jul;
103(11):2077-2084.
PMID: 35839921
Objective: To investigate the effect of aerobic exercise vs control (stretching/balance) on inflammatory and oxidative stress biomarkers in stroke survivors and whether these changes are associated with improvements in physical...
9.
Robbins R, Kelleher J, Vellanki P, OConnor J, Mascaro J, Nocera J, et al.
J Funct Morphol Kinesiol
. 2022 Jun;
7(2).
PMID: 35736016
This pilot examines whether resistance training (RT) can induce changes in kynurenine (KYN) metabolism, which may contribute to improved physical function in breast cancer survivors (BCSs). Thirty-six BCSs (63.2 ±...
10.
Porter G, OConnor J
Neurol Neurobiol (Tallinn)
. 2022 Jun;
4(3).
PMID: 35662811
Chronic stress is a well-known risk factor in major depressive disorder and disrupts the kynurenine and serotonin pathways of tryptophan metabolism. Here, we characterize the temporal central and peripheral changes...