Robert H McCusker
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Explore the profile of Robert H McCusker including associated specialties, affiliations and a list of published articles.
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50
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1181
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Recent Articles
1.
Butler M, Muscat S, Caetano-Silva M, Shrestha A, Olmo B, Mackey-Alfonso S, et al.
Immun Ageing
. 2025 Jan;
22(1):2.
PMID: 39754121
Background: Obesity and metabolic syndrome are major public health concerns linked to cognitive decline with aging. Prior work from our lab has demonstrated that short-term high fat diet (HFD) rapidly...
2.
Sukka S, Ampomah P, Darville L, Ngai D, Wang X, Kuriakose G, et al.
Nat Metab
. 2024 Sep;
6(11):2204.
PMID: 39285251
No abstract available.
3.
Sukka S, Ampomah P, Darville L, Ngai D, Wang X, Kuriakose G, et al.
Nat Metab
. 2024 Sep;
6(9):1736-1755.
PMID: 39242914
Macrophage efferocytosis prevents apoptotic cell (AC) accumulation and triggers inflammation-resolution pathways. The mechanisms linking efferocytosis to resolution often involve changes in macrophage metabolism, but many gaps remain in our understanding...
4.
Tousif S, Wang Y, Jackson J, Hough K, Strenkowski J, Athar M, et al.
Front Immunol
. 2021 Dec;
12:747780.
PMID: 34867973
Regulatory B cells (Breg) are IL-10 producing subsets of B cells that contribute to immunosuppression in the tumor microenvironment (TME). Breg are elevated in patients with lung cancer; however, the...
5.
Wetzel L, Hurtado M, MacDowell Kaswan Z, McCusker R, Steelman A
Brain Behav Immun Health
. 2021 Sep;
7:100116.
PMID: 34589873
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) with pathological features of inflammation, demyelination, and neurodegeneration. Several lines of evidence suggest that the enzymes indoleamine...
6.
Zhai L, Bell A, Ladomersky E, Lauing K, Bollu L, Sosman J, et al.
Front Immunol
. 2020 Jul;
11:1185.
PMID: 32612606
Indoleamine 2, 3-dioxygenase 1 (IDO; IDO1; INDO) is a rate-limiting enzyme that metabolizes the essential amino acid, tryptophan, into downstream kynurenines. Canonically, the metabolic depletion of tryptophan and/or the accumulation...
7.
Towers A, Oelschlager M, Lorenz M, Gainey S, McCusker R, Krauklis S, et al.
Brain Behav Immun
. 2019 May;
80:763-776.
PMID: 31108171
Acute stressors can induce fear and physiologic responses that prepare the body to protect from danger. A key component of this response is immune system readiness. In particular, inflammasome activation...
8.
Juda M, Brooks A, Towers A, Freund G, McCusker R, Steelman A
Epilepsia
. 2019 Feb;
60(4):626-635.
PMID: 30770561
Objective: Viral encephalitis increases the risk for developing seizures and epilepsy. Indoleamine 2,3-dioxygenase 1 (Ido1) is induced by inflammatory cytokines and functions to metabolize tryptophan to kynurenine. Kynurenine can be...
9.
Mailing L, Allen J, Pence B, Rytych J, Sun Y, Bhattacharya T, et al.
Behav Brain Res
. 2018 Sep;
359:731-736.
PMID: 30243767
Recent data has supported a role for the gut microbiota in improving cognition and shaping behavior. Here, we assessed whether pectin, a soluble, fermentable fiber, could enhance learning and memory...
10.
Rodriguez-Zas S, Wu C, Southey B, OConnor J, Nixon S, Garcia R, et al.
Psychoneuroendocrinology
. 2018 Jul;
97:47-58.
PMID: 30005281
Background: Peripheral immune challenge can elicit microglia activation and depression-related symptoms. The balance of inflammatory signals in the tryptophan pathway can skew the activity of indoleamine-pyrrole 2,3 dioxygenase (IDO1) towards...