Jason C OConnor
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Explore the profile of Jason C OConnor including associated specialties, affiliations and a list of published articles.
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62
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5238
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Recent Articles
11.
Porter G, OConnor J
World J Psychiatry
. 2022 Feb;
12(1):77-97.
PMID: 35111580
Major depressive disorder is a debilitating disorder affecting millions of people each year. Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk factors in the pathogenesis of depression...
12.
Parrott J, Porter G, Redus L, OConnor J
Psychoneuroendocrinology
. 2021 Oct;
134:105404.
PMID: 34601342
Brain-derived neurotrophic factor (BDNF) is implicated in the pathology of major depression and influences the inflammatory response. Prolonged immune system activation can cause depression symptoms, and individuals with low BDNF...
13.
Porter G, Straud C, OConnor J, Knopf K, Roberts D
Community Ment Health J
. 2021 Sep;
58(4):806-811.
PMID: 34537929
This article describes the rate of suicidal ideation (SI) across three timepoints among treatment-seeking patients recently discharged from psychiatric hospitalization-a group that is at ultrahigh-risk for suicide. Retrospective chart review...
14.
Santana-Coelho D, Layne-Colon D, Valdespino R, Ross C, Tardif S, OConnor J
Front Psychiatry
. 2021 Aug;
12:705554.
PMID: 34421684
Understanding the mechanism(s) by which maternal immune activation (MIA) during gestation may disrupt neurodevelopment and increase the susceptibility for disorders such as autism spectrum disorder (ASD) or schizophrenia is a...
15.
Mithaiwala M, Santana-Coelho D, Porter G, OConnor J
Cells
. 2021 Jul;
10(6).
PMID: 34205235
Diseases of the central nervous system (CNS) remain a significant health, social and economic problem around the globe. The development of therapeutic strategies for CNS conditions has suffered due to...
16.
Debnath S, Lorenzo C, Bansal S, Morales J, Rueda R, Kasinath B, et al.
Am J Nephrol
. 2020 Jun;
51(7):565-571.
PMID: 32575099
Background: Fatigue is one of the most debilitating symptoms reported by maintenance hemodialysis (MHD) patients. Hemodialysis causes marked depletion in plasma essential amino acids. We studied the cross-sectional relationship of...
17.
Chen C, Guderyon M, Li Y, Ge G, Bhattacharjee A, Ballard C, et al.
Mol Ther Methods Clin Dev
. 2020 Jan;
17:83-98.
PMID: 31890743
Glial cell-line-derived neurotrophic factor (GDNF) is a potent neuroprotective agent in cellular and animal models of Parkinson's disease (PD). However, CNS delivery of GDNF in clinical trials has proven challenging...
18.
Lu Y, Sareddy G, Wang J, Wang R, Li Y, Dong Y, et al.
J Neurosci
. 2019 Feb;
39(15):2792-2809.
PMID: 30728170
17β-estradiol (E2) is produced from androgens via the action of the enzyme aromatase. E2 is known to be made in neurons in the brain, but its precise functions in the...
19.
Garrison A, Parrott J, Tunon A, Delgado J, Redus L, OConnor J
Psychoneuroendocrinology
. 2018 Sep;
98:231-232.
PMID: 30193762
No abstract available.
20.
Bhattacharya A, Lord B, Grigoleit J, He Y, Fraser I, Campbell S, et al.
Neuropsychopharmacology
. 2018 Jul;
43(13):2586-2596.
PMID: 30026598
Emerging data continues to point towards a relationship between neuroinflammation and neuropsychiatric disorders. ATP-induced activation of P2X7 results in IL-1β release causing neuroinflammation and microglial activation. This study describes the...