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Jarrett D Egertson

Explore the profile of Jarrett D Egertson including associated specialties, affiliations and a list of published articles. Areas
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Articles 19
Citations 1616
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Recent Articles
1.
Campbell M, Martin-Perez M, Egertson J, Gaffrey M, Wang L, Bammler T, et al.
Geroscience . 2022 Nov; 44(6):2913-2924. PMID: 36322234
The age-related decline in skeletal muscle mass and function is known as sarcopenia. Sarcopenia progresses based on complex processes involving protein dynamics, cell signaling, oxidative stress, and repair. We have...
2.
Campbell M, Duan J, Samuelson A, Gaffrey M, Merrihew G, Egertson J, et al.
Free Radic Biol Med . 2019 Jan; 134:268-281. PMID: 30597195
Sarcopenia and exercise intolerance are major contributors to reduced quality of life in the elderly for which there are few effective treatments. We tested whether enhancing mitochondrial function and reducing...
3.
Searle B, Pino L, Egertson J, Ting Y, Lawrence R, MacLean B, et al.
Nat Commun . 2018 Dec; 9(1):5128. PMID: 30510204
Data independent acquisition (DIA) mass spectrometry is a powerful technique that is improving the reproducibility and throughput of proteomics studies. Here, we introduce an experimental workflow that uses this technique...
4.
Kim Y, Sweet S, Egertson J, Sedgewick A, Woo S, Liao W, et al.
J Proteome Res . 2018 Nov; 18(1):426-435. PMID: 30481034
Mass spectrometry-based protein quantitation is currently used to measure therapeutically relevant protein biomarkers in CAP/CLIA setting to predict likely responses of known therapies. Selected reaction monitoring (SRM) is the method...
5.
MacLean B, Pratt B, Egertson J, MacCoss M, Smith R, Baker E
J Am Soc Mass Spectrom . 2018 Jul; 29(11):2182-2188. PMID: 30047074
Recent advances in ion mobility spectrometry (IMS) have illustrated its power in determining the structural characteristics of a molecule, especially when coupled with other separations dimensions such as liquid chromatography...
6.
Litichevskiy L, Peckner R, Abelin J, Asiedu J, Creech A, Davis J, et al.
Cell Syst . 2018 Apr; 6(4):424-443.e7. PMID: 29655704
Although the value of proteomics has been demonstrated, cost and scale are typically prohibitive, and gene expression profiling remains dominant for characterizing cellular responses to perturbations. However, high-throughput sentinel assays...
7.
Peckner R, Myers S, Jacome A, Egertson J, Abelin J, MacCoss M, et al.
Nat Methods . 2018 Apr; 15(5):371-378. PMID: 29608554
Mass spectrometry with data-independent acquisition (DIA) is a promising method to improve the comprehensiveness and reproducibility of targeted and discovery proteomics, in theory by systematically measuring all peptide precursors in...
8.
Galitzine C, Egertson J, Abbatiello S, Henderson C, Pino L, MacCoss M, et al.
Mol Cell Proteomics . 2018 Feb; 17(5):913-924. PMID: 29438992
The need for assay characterization is ubiquitous in quantitative mass spectrometry-based proteomics. Among many assay characteristics, the limit of blank (LOB) and limit of detection (LOD) are two particularly useful...
9.
Ting Y, Egertson J, Bollinger J, Searle B, Payne S, Noble W, et al.
Nat Methods . 2017 Aug; 14(9):903-908. PMID: 28783153
Data-independent acquisition (DIA) is an emerging mass spectrometry (MS)-based technique for unbiased and reproducible measurement of protein mixtures. DIA tandem mass spectrometry spectra are often highly multiplexed, containing product ions...
10.
Bollinger J, Stergachis A, Johnson R, Egertson J, MacCoss M
Methods Mol Biol . 2016 Feb; 1410:207-21. PMID: 26867746
In targeted proteomics, the development of robust methodologies is dependent upon the selection of a set of optimal peptides for each protein-of-interest. Unfortunately, predicting which peptides and respective product ion...