Brian C Searle
Overview
Explore the profile of Brian C Searle including associated specialties, affiliations and a list of published articles.
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54
Citations
1716
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Recent Articles
1.
Searle B, Chazarin B, Collins B, Kundu D, Huang S, Lin Q, et al.
J Proteome Res
. 2025 Feb;
24(2):381-382.
PMID: 39916559
No abstract available.
2.
Meyer A, Meyer A, McIlvin M, Lopez P, Searle B, Saito M
bioRxiv
. 2025 Jan;
PMID: 39868216
Zinc is central to the function of many proteins, yet the mechanisms of zinc homeostasis and their interplay with other cellular systems remain underexplored. In this study, we employ data-dependent...
3.
Searle B
Curr Opin Struct Biol
. 2024 Oct;
89:102946.
PMID: 39481280
Thermal proteome profiling (TPP) is an innovative technique that uses the principle of protein thermal stability to identify potential protein interaction partners. Employing quantitative mass spectrometry, TPP measures protein stability...
4.
Rajczewski A, Blakeley-Ruiz J, Meyer A, Vintila S, McIlvin M, Van Den Bossche T, et al.
bioRxiv
. 2024 Sep;
PMID: 39345414
Mass spectrometry (MS)-based metaproteomics is used to identify and quantify proteins in microbiome samples, with the frequently used methodology being Data-Dependent Acquisition mass spectrometry (DDA-MS). However, DDA-MS is limited in...
5.
Ghosh G, Shannon A, Searle B
Proteomics
. 2024 Aug;
25(1-2):e2400022.
PMID: 39088833
Single-cell proteomics (SCP) aims to characterize the proteome of individual cells, providing insights into complex biological systems. It reveals subtle differences in distinct cellular populations that bulk proteome analysis may...
6.
Shannon A, Teodorescu R, Soon N, Heil L, Jacob C, Remes P, et al.
bioRxiv
. 2024 Jun;
PMID: 38853838
Advances in proteomics and mass spectrometry have enabled the study of limited cell populations, such as single-cell proteomics, where high-mass accuracy instruments are typically required. While triple quadrupoles offer fast...
7.
Akshintala V, Moore M, Cruz-Monserrate Z, Nathan J, Searle B, Abu-El-Haija M
Gastroenterology
. 2024 May;
167(5):1019-1021.e2.
PMID: 38797238
No abstract available.
8.
9.
Shannon A, Boos C, Searle B, Hummon A
J Proteome Res
. 2024 Feb;
23(8):3188-3199.
PMID: 38412258
Colorectal cancer (CRC) contains considerable heterogeneity; therefore, models of the disease must also reflect the multifarious components. Compared to traditional 2D models, 3D cellular models, such as tumor spheroids, have...
10.
Joyce A, Searle B
Proteomics
. 2023 Oct;
24(8):e2300088.
PMID: 37897210
Due to their oftentimes ambiguous nature, phosphopeptide positional isomers can present challenges in bottom-up mass spectrometry-based workflows as search engine scores alone are often not enough to confidently distinguish them....