Ralph J S van Mechelen
Overview
Explore the profile of Ralph J S van Mechelen including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
40
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0
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Recent Articles
1.
Pereira I, van Mechelen R, Wyss H, Pinchuk L, Beckers H, den Toonder J
Microsyst Nanoeng
. 2023 Jul;
9:92.
PMID: 37484503
The key risk factor for glaucoma is increased intraocular pressure (IOP). Glaucoma drainage devices implanted in the eye can reduce IOP and thus stop disease progression. However, most devices currently...
2.
van Mechelen R, Wolters J, Fredrich S, Bertens C, Gijbels M, Schenning A, et al.
Macromol Biosci
. 2023 May;
23(10):e2300075.
PMID: 37249127
Fibrosis of the filtering bleb is one of the main causes of failure after bleb-forming glaucoma surgery. Intraoperative application of mitomycin C (MMC) is the current gold standard to reduce...
3.
van Mechelen R, Sudarsanam P, Bertens C, Tas M, Gijbels M, Pinchuk L, et al.
Adv Biol (Weinh)
. 2023 Apr;
7(7):e2300051.
PMID: 37102630
Lowering intraocular pressure (IOP) by placement of a glaucoma shunt is an effective treatment for glaucoma. However, fibrosis of the outflow site can hamper surgical outcome. In this study, the...
4.
van Mechelen R, Wolters J, Herfs M, Bertens C, Gijbels M, Pinchuk L, et al.
Transl Vis Sci Technol
. 2022 Aug;
11(8):29.
PMID: 36018582
Purpose: The PreserFlo MicroShunt is an innovative implant for the surgical treatment of glaucoma. Although usually effective, surgeries can still fail due to fibrosis. This study was conducted to gain...
5.
van Mechelen R, Wolters J, Bertens C, Webers C, Biggelaar F, Gorgels T, et al.
Exp Eye Res
. 2022 Feb;
217:108972.
PMID: 35114212
Glaucoma, a degenerative disease of the optic nerve, is the leading cause of irreversible blindness worldwide. Currently, there is no curative treatment. The only proven treatment is lowering intraocular pressure...
6.
Bertens C, van Mechelen R, Berendschot T, Gijs M, Wolters J, Gorgels T, et al.
Sci Rep
. 2021 Sep;
11(1):19217.
PMID: 34584185
The aim of this study was to evaluate repeatability, reproducibility, and agreement of three commonly used tonometers in animal research (TonoLab, TonoVet, and TonoPEN AVIA) in a cohort of 24...
7.
Wolters J, van Mechelen R, Al Majidi R, Pinchuk L, Webers C, Beckers H, et al.
Curr Opin Ophthalmol
. 2020 Dec;
32(2):148-159.
PMID: 33315724
Purpose Of Review: Mitomycin C (MMC) is an alkylating agent with extraordinary ability to crosslink DNA, preventing DNA synthesis. By this virtue, MMC is an important antitumor drug. In addition,...