Lize Deferme
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Explore the profile of Lize Deferme including associated specialties, affiliations and a list of published articles.
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10
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109
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Recent Articles
1.
Verstraelen S, Jacobs A, Van Laer J, Hollanders K, Van Deun M, Bertels D, et al.
ALTEX
. 2021 Apr;
38(4):550-564.
PMID: 33882577
The goal is to optimize and show the validity of an in vitro method for inhalation testing of petroleum substances and their constituents at the air-liquid interface (ALI). The approach...
2.
Boogaard P, Buschmann J, Fuhst R, Blumlein K, Koch W, Schaudien D, et al.
Reprod Toxicol
. 2021 Mar;
102:67-79.
PMID: 33781938
The prenatal developmental toxicity of the fumes of oxidised asphalt (OA) was tested by nose-only inhalation in the rat. The test material was generated by collecting fumes from the headspace...
3.
Boogaard P, Buschmann J, Fuhst R, Blumlein K, Schwarz K, Schaudien D, et al.
Reprod Toxicol
. 2020 Nov;
99:15-26.
PMID: 33249228
The prenatal developmental toxicity of bitumen fume was tested by nose-only inhalation in the rat. The fumes for exposure were collected from the headspace of a storage tank filled with...
4.
Briede J, Deferme L, Wolters J, Claessen S, van den Beucken T, Wagner R, et al.
Toxicol In Vitro
. 2018 Feb;
48:318-328.
PMID: 29432895
Regulation of DNA methylation plays a crucial role in biological processes and carcinogenesis. The formation of 5-hydroxymethylcytosine (5hmC) by oxidation of 5-methylcytosine (5mC) has been proposed as an intermediate of...
5.
Bridges J, Sauer U, Buesen R, Deferme L, Tollefsen K, Tralau T, et al.
Regul Toxicol Pharmacol
. 2017 Oct;
91 Suppl 1:S46-S60.
PMID: 29037774
A framework for the quantitative weight-of-evidence (QWoE) analysis of 'omics data for regulatory purposes is presented. The QWoE framework encompasses seven steps to evaluate 'omics data (also together with non-'omics...
6.
Kauffmann H, Kamp H, Fuchs R, Chorley B, Deferme L, Ebbels T, et al.
Regul Toxicol Pharmacol
. 2017 Oct;
91 Suppl 1:S27-S35.
PMID: 28987912
'Omics technologies are gaining importance to support regulatory toxicity studies. Prerequisites for performing 'omics studies considering GLP principles were discussed at the European Centre for Ecotoxicology and Toxicology of Chemicals...
7.
Buesen R, Chorley B, Lima B, Daston G, Deferme L, Ebbels T, et al.
Regul Toxicol Pharmacol
. 2017 Sep;
91 Suppl 1:S3-S13.
PMID: 28958911
Prevailing knowledge gaps in linking specific molecular changes to apical outcomes and methodological uncertainties in the generation, storage, processing, and interpretation of 'omics data limit the application of 'omics technologies...
8.
Sauer U, Deferme L, Gribaldo L, Hackermuller J, Tralau T, van Ravenzwaay B, et al.
Regul Toxicol Pharmacol
. 2017 Sep;
91 Suppl 1:S14-S26.
PMID: 28927750
This survey by the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) highlights that 'omics technologies are generally not yet applied to meet standard information requirements during regulatory hazard...
9.
Deferme L, Wolters J, Claessen S, Theunissen D, van den Beucken T, Wagner J, et al.
Chem Res Toxicol
. 2016 Aug;
29(9):1428-38.
PMID: 27509014
In recent years, it has been shown that free radicals not only react directly with DNA but also regulate epigenetic processes such as DNA methylation, which may be relevant within...
10.
Oxidative Stress Mechanisms Do Not Discriminate between Genotoxic and Nongenotoxic Liver Carcinogens
Deferme L, Wolters J, Claessen S, Briede J, Kleinjans J
Chem Res Toxicol
. 2015 Jul;
28(8):1636-46.
PMID: 26198647
It is widely accepted that in chemical carcinogenesis different modes-of-action exist, e.g., genotoxic (GTX) versus nongenotoxic (NGTX) carcinogenesis. In this context, it has been suggested that oxidative stress response pathways...