Jared M Lucas
Overview
Explore the profile of Jared M Lucas including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
1963
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0
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Recent Articles
1.
Nyquist M, Coleman I, Lucas J, Li D, Hanratty B, Meade H, et al.
Cancer Res
. 2023 Jun;
83(17):2938-2951.
PMID: 37352376
Significance: Determining the molecular pathways by which supraphysiological androgens promote growth arrest and treatment responses in prostate cancer provides opportunities for biomarker-selected clinical trials and the development of strategies to...
2.
De Sarkar N, Patton R, Doebley A, Hanratty B, Adil M, Kreitzman A, et al.
Cancer Discov
. 2022 Nov;
13(3):632-653.
PMID: 36399432
Significance: This study provides insights into the dynamics of nucleosome positioning and gene regulation associated with cancer phenotypes that can be ascertained from ctDNA. New methods for classification in phenotype...
3.
Patel R, Coleman I, Roudier M, Konnick E, Hanratty B, Dumpit R, et al.
Cancer Res Commun
. 2022 Nov;
2(5):277-285.
PMID: 36337169
Anaplastic lymphoma kinase (ALK) is a tyrosine kinase with genomic and expression changes in many solid tumors. ALK inhibition is first line therapy for lung cancers with alterations, and an...
4.
De Sarkar N, Dasgupta S, Chatterjee P, Coleman I, Ha G, Ang L, et al.
JCI Insight
. 2021 Dec;
6(23).
PMID: 34877933
Cancers with homology-directed DNA repair (HRR) deficiency exhibit high response rates to poly(ADP-ribose) polymerase inhibitors (PARPi) and platinum chemotherapy. Though mutations disrupting BRCA1 and BRCA2 associate with HRR deficiency (HRRd),...
5.
Kim D, Sun D, Storck W, Welker Leng K, Jenkins C, Coleman D, et al.
Clin Cancer Res
. 2021 Jun;
27(17):4923-4936.
PMID: 34145028
Purpose: Lineage plasticity in prostate cancer-most commonly exemplified by loss of androgen receptor (AR) signaling and a switch from a luminal to alternate differentiation program-is now recognized as a treatment...
6.
Corella A, Cabiliza Ordonio M, Coleman I, Lucas J, Kaipainen A, Nguyen H, et al.
Clin Cancer Res
. 2019 Dec;
26(7):1667-1677.
PMID: 31806643
Purpose: Small-cell neuroendocrine prostate cancer (SCNPC) exhibits an aggressive clinical course and incidence rates seem to be increasing following resistance to potent androgen receptor (AR) antagonists. Currently, treatment options are...
7.
Nyquist M, Corella A, Mohamad O, Coleman I, Kaipainen A, Kuppers D, et al.
JCI Insight
. 2019 Sep;
4(19).
PMID: 31503550
Clinical trials of high-dose androgen (HDA) therapy for prostate cancer (PC) have shown promising efficacy but are limited by lack of criteria to identify likely responders. To elucidate factors that...
8.
Chatterjee P, Schweizer M, Lucas J, Coleman I, Nyquist M, Frank S, et al.
J Clin Invest
. 2019 Jul;
129(10):4245-4260.
PMID: 31310591
Prostate cancer (PC) is initially dependent on androgen receptor (AR) signaling for survival and growth. Therapeutics designed to suppress AR activity serve as the primary intervention for advanced disease. However,...
9.
Bluemn E, Coleman I, Lucas J, Coleman R, Hernandez-Lopez S, Tharakan R, et al.
Cancer Cell
. 2017 Oct;
32(4):474-489.e6.
PMID: 29017058
Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and represents the major therapeutic target for treating metastatic prostate cancer (mPC). Though highly effective, AR antagonism can...
10.
Yamazaki T, Sugisawa R, Hiramoto E, Takai R, Matsumoto A, Senda Y, et al.
Sci Rep
. 2016 Dec;
6:38762.
PMID: 27929116
Apoptosis inhibitor of macrophage (AIM, encoded by cd5l) is a multi-functional circulating protein that has a beneficial role in the regulation of a broad range of diseases, some of which...