Janos Sagi
Overview
Explore the profile of Janos Sagi including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
306
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Recent Articles
1.
Dvorakova Z, Renciuk D, Kejnovska I, Skolakova P, Bednarova K, Sagi J, et al.
Nucleic Acids Res
. 2018 Jan;
46(4):1624-1634.
PMID: 29378012
i-Motif (iM) is a four stranded DNA structure formed by cytosine-rich sequences, which are often present in functionally important parts of the genome such as promoters of genes and telomeres....
2.
Sagi J
J Nucleic Acids
. 2017 Nov;
2017:1641845.
PMID: 29181193
Synthetic analogs of natural nucleotides have long been utilized for structural studies of canonical and noncanonical nucleic acids, including the extensively investigated polymorphic G-quadruplexes (GQs). Dependence on the sequence and...
3.
Kejnovska I, Bednarova K, Renciuk D, Dvorakova Z, Skolakova P, Trantirek L, et al.
Nucleic Acids Res
. 2017 Apr;
45(8):4294-4305.
PMID: 28369584
Ionizing radiation produces clustered damage to DNA which is difficult to repair and thus more harmful than single lesions. Clustered lesions have only been investigated in dsDNA models. Introducing the...
4.
Konvalinova H, Dvorakova Z, Renciuk D, Bednarova K, Kejnovska I, Trantirek L, et al.
Biochimie
. 2015 Jul;
118:15-25.
PMID: 26188111
Various base lesions continuously form in cellular nucleic acids and the unrepaired lesions are promutagenic and procarcinogenic. Though natural base lesions have been extensively studied in double-stranded DNA models, these...
5.
Babinsky M, Fiala R, Kejnovska I, Bednarova K, Marek R, Sagi J, et al.
Nucleic Acids Res
. 2014 Nov;
42(22):14031-41.
PMID: 25428355
Abasic (AP) lesions are the most frequent type of damages occurring in cellular DNA. Here we describe the conformational effects of AP sites substituted for 2'-deoxyadenosine in the first (ap7),...
6.
Kejnovska I, Vorlickova M, Brazdova M, Sagi J
Biopolymers
. 2013 Sep;
101(4):428-38.
PMID: 24037480
For mimicking macromolecular crowding of DNA quadruplexes, various crowding agents have been used, typically PEG, with quadruplexes of micromolar strand concentrations. Thermal and thermodynamic stabilities of these quadruplexes increased with...
7.
Sagi J
J Biomol Struct Dyn
. 2013 Mar;
32(3):477-511.
PMID: 23528013
This review summarizes the results of structural studies carried out with analogs of G-quadruplexes built from natural nucleotides. Several dozens of base-, sugar-, and phosphate derivatives of the biological building...
8.
Vorlickova M, Kejnovska I, Sagi J, Renciuk D, Bednarova K, Motlova J, et al.
Methods
. 2012 Mar;
57(1):64-75.
PMID: 22450044
Circular dichroism (CD) is remarkably sensitive to the conformational states of nucleic acids; therefore, CD spectroscopy has been used to study most features of DNA and RNA structures. Quadruplexes are...
9.
Vorlickova M, Tomasko M, Sagi A, Bednarova K, Sagi J
FEBS J
. 2011 Oct;
279(1):29-39.
PMID: 22008383
8-Oxoguanine is a ubiquitous oxidative base lesion. We report here on the effect of this lesion on the structure and stability of quadruplexes formed by the human telomeric DNA sequence...
10.
Skolakova P, Bednarova K, Vorlickova M, Sagi J
Biochem Biophys Res Commun
. 2010 Jul;
399(2):203-8.
PMID: 20643102
This study was performed to evaluate how the loss of a guanine base affects the structure and stability of the three-tetrad G-quadruplex of 5'-dG(3)(TTAG(3))(3), the basic quadruplex-forming unit of the...