Iva Kejnovska
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Explore the profile of Iva Kejnovska including associated specialties, affiliations and a list of published articles.
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41
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1189
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Recent Articles
1.
Smeds L, Kamali K, Kejnovska I, Kejnovsky E, Chiaromonte F, Makova K
bioRxiv
. 2024 Dec;
PMID: 39713403
Non-canonical (non-B) DNA structures-e.g., bent DNA, hairpins, G-quadruplexes, Z-DNA, etc.-which form at certain sequence motifs (e.g., A-phased repeats, inverted repeats, etc.), have emerged as important regulators of cellular processes and...
2.
Basu P, Kejnovska I, Gajarsky M, Subert D, Mikesova T, Renciuk D, et al.
Nucleic Acids Res
. 2024 Nov;
52(21):13224-13242.
PMID: 39494519
G-quadruplexes (G4s) formed within RNA are emerging as promising targets for therapeutic intervention in cancer, neurodegenerative disorders and infectious diseases. Sequences containing a succession of short GG blocks, or uneven...
3.
Jedlicka P, Tokan V, Kejnovska I, Hobza R, Kejnovsky E
Mob DNA
. 2023 Apr;
14(1):3.
PMID: 37038191
Background: Canonical telomeres (telomerase-synthetised) are readily forming G-quadruplexes (G4) on the G-rich strand. However, there are examples of non-canonical telomeres among eukaryotes where telomeric tandem repeats are invaded by specific...
4.
Variation in G-quadruplex sequence and topology differentially impacts human DNA polymerase fidelity
Stein M, Hile S, Weissensteiner M, Lee M, Zhang S, Kejnovsky E, et al.
DNA Repair (Amst)
. 2022 Sep;
119:103402.
PMID: 36116264
G-quadruplexes (G4s), a type of non-B DNA, play important roles in a wide range of molecular processes, including replication, transcription, and translation. Genome integrity relies on efficient and accurate DNA...
5.
Novotny A, Novotny J, Kejnovska I, Vorlickova M, Fiala R, Marek R
Nucleic Acids Res
. 2021 Oct;
49(20):11425-11437.
PMID: 34718718
Non-canonical forms of nucleic acids represent challenging objects for both structure-determination and investigation of their potential role in living systems. In this work, we uncover a structure adopted by GA...
6.
Kejnovska I, Stadlbauer P, Trantirek L, Renciuk D, Gajarsky M, Krafcik D, et al.
Chemistry
. 2021 Jun;
27(47):12115-12125.
PMID: 34145655
Guanine quadruplexes (G4s) are noncanonical forms of nucleic acids that are frequently found in genomes. The stability of G4s depends, among other factors, on the number of G-tetrads. Three- or...
7.
Quadruplex-Forming Motif Inserted into 3'UTR of Retrotransposon Inhibits Retrotransposition in Yeast
Tokan V, Rodriguez Lorenzo J, Jedlicka P, Kejnovska I, Hobza R, Kejnovsky E
Biology (Basel)
. 2021 Apr;
10(4).
PMID: 33924086
Guanine quadruplexes (G4s) serve as regulators of replication, recombination and gene expression. G4 motifs have been recently identified in LTR retrotransposons, but their role in the retrotransposon life-cycle is yet...
8.
Bednarova K, Kejnovska I, Vorlickova M, Renciuk D
Chemistry
. 2019 Aug;
25(58):13422-13428.
PMID: 31453656
Guanine quadruplexes, recently reported to form in vivo, represent a broad spectrum of non-canonical conformations of nucleic acids. The actual conformation might differ between water solutions and crowding or dehydrating...
9.
Kejnovska I, Renciuk D, Palacky J, Vorlickova M
Methods Mol Biol
. 2019 Aug;
2035:25-44.
PMID: 31444742
Circular Dichroic (CD) spectroscopy is one of the most frequently used methods for guanine quadruplex studies and in general for studies of conformational properties of nucleic acids. The reason is...
10.
Skolakova P, Renciuk D, Palacky J, Krafcik D, Dvorakova Z, Kejnovska I, et al.
Nucleic Acids Res
. 2019 Feb;
47(5):2177-2189.
PMID: 30715498
The formation of intercalated motifs (iMs) - secondary DNA structures based on hemiprotonated C.C+ pairs in suitable cytosine-rich DNA sequences, is reflected by typical changes in CD and UV absorption...