Janny G P Peters
Overview
Explore the profile of Janny G P Peters including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
391
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0
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Recent Articles
1.
Vormann M, Vriend J, Lanz H, Gijzen L, van den Heuvel A, Hutter S, et al.
J Pharm Sci
. 2021 Feb;
110(4):1601-1614.
PMID: 33545187
Proximal tubule epithelial cells (PTEC) are susceptible to drug-induced kidney injury (DIKI). Cell-based, two-dimensional (2D) in vitro PTEC models are often poor predictors of DIKI, probably due to the lack...
2.
Vriend J, Peters J, Nieskens T, Skovronova R, Blaimschein N, Schmidts M, et al.
Biochim Biophys Acta Gen Subj
. 2019 Sep;
1864(1):129433.
PMID: 31520681
Background: Kidney disease modeling and assessment of drug-induced kidney injury can be advanced using three-dimensional (3D) microfluidic models that recapitulate in vivo characteristics. Fluid shear stress (FSS) has been depicted...
3.
Nieskens T, Peters J, Dabaghie D, Korte D, Jansen K, Van Asbeck A, et al.
Drug Metab Dispos
. 2018 Mar;
46(5):592-599.
PMID: 29514829
Cisplatin is a cytostatic drug used for treatment of solid organ tumors. The main adverse effect is organic cation transporter 2 (OCT2)-mediated nephrotoxicity, observed in 30% of patients. The contribution...
4.
Nieskens T, Peters J, Schreurs M, Smits N, Woestenenk R, Jansen K, et al.
AAPS J
. 2016 Jan;
18(2):465-75.
PMID: 26821801
Drug-induced nephrotoxicity still hampers drug development, because current translation from in vitro or animal studies to human lacks high predictivity. Often, renal adverse effects are recognized only during clinical stages...
5.
Wever K, Masereeuw R, Wagener F, Verweij V, Peters J, Pertijs J, et al.
Nephrol Dial Transplant
. 2013 Feb;
28(7):1721-32.
PMID: 23389998
Background: Renal ischaemia-reperfusion injury (IRI) is a common clinical problem associated with significant mortality and morbidity. One strategy to reduce this damage is remote ischaemic preconditioning (RIPC), in which brief...
6.
Dieteren C, Koopman W, Swarts H, Peters J, Maczuga P, Van Gemst J, et al.
J Biol Chem
. 2012 Oct;
287(50):41851-60.
PMID: 23038253
Studies employing native PAGE suggest that most nDNA-encoded CI subunits form subassemblies before assembling into holo-CI. In addition, in vitro evidence suggests that some subunits can directly exchange in holo-CI....
7.
van Swelm R, Laarakkers C, Blous L, Peters J, Blaney Davidson E, van der Kraan P, et al.
Toxicol Sci
. 2012 May;
129(1):225-33.
PMID: 22610607
Acetaminophen (APAP), a major cause of acute liver injury in the Western world, is mediated by metabolism and oxidative stress. Recent studies have suggested a role for iron in potentiating...
8.
Heemskerk S, Peters J, Louisse J, Sagar S, Russel F, Masereeuw R
J Biomed Biotechnol
. 2010 Mar;
2010:525180.
PMID: 20300455
During endotoxemia, the ATP-dependent drug efflux pump P-glycoprotein (Abcb1/P-gp) is upregulated in kidney proximal tubule epithelial cells. The signaling pathway through which lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF-alpha) regulates...
9.
van de Water F, Boleij J, Peters J, Russel F, Masereeuw R
Eur J Pharm Sci
. 2006 Nov;
30(1):36-44.
PMID: 17088052
The activity of P-glycoprotein (Pgp/MDR1/ABCB1) and multidrug resistance proteins (MRP/ABCC) influence the pharmacokinetics and bioavailability of many drugs. Few suitable cell lines for the study of drug transport exist. Additional...
10.
van de Water F, Boerman O, Wouterse A, Peters J, Russel F, Masereeuw R
Drug Metab Dispos
. 2006 May;
34(8):1393-7.
PMID: 16714375
Different gene-silencing methods, like antisense and short interfering RNA (siRNA), are widely used as experimental tools to inhibit gene expression. In the present study, the in vivo behavior of siRNA...