Tom T G Nieskens
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Explore the profile of Tom T G Nieskens including associated specialties, affiliations and a list of published articles.
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11
Citations
277
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Recent Articles
1.
Nieskens T, Magnusson O, Andersson P, Soderberg M, Persson M, Sjogren A
Arch Toxicol
. 2021 May;
95(6):2123-2136.
PMID: 33961089
Antisense oligonucleotides (ASOs) are a promising therapeutic modality. However, failure to predict acute kidney injury induced by SPC5001 ASO observed in a clinical trial suggests the need for additional preclinical...
2.
Vormann M, Vriend J, Lanz H, Gijzen L, van den Heuvel A, Hutter S, et al.
J Pharm Sci
. 2021 Feb;
110(4):1601-1614.
PMID: 33545187
Proximal tubule epithelial cells (PTEC) are susceptible to drug-induced kidney injury (DIKI). Cell-based, two-dimensional (2D) in vitro PTEC models are often poor predictors of DIKI, probably due to the lack...
3.
Nieskens T, Persson M, Kelly E, Sjogren A
Drug Metab Dispos
. 2020 Oct;
48(12):1303-1311.
PMID: 33020068
Drug-induced kidney injury is a major clinical problem and causes drug attrition in the pharmaceutical industry. To better predict drug-induced kidney injury, kidney in vitro cultures with enhanced physiologic relevance...
4.
Janssen M, Nieskens T, Steevels T, Caetano-Pinto P, den Braanker D, Mulder M, et al.
Mol Ther Nucleic Acids
. 2019 Oct;
18:298-307.
PMID: 31610379
Antisense oligonucleotide therapy has been reported to be associated with renal injury. Here, the mechanism of reversible proteinuria was investigated by combining clinical, pre-clinical, and in vitro data. Urine samples...
5.
Vriend J, Peters J, Nieskens T, Skovronova R, Blaimschein N, Schmidts M, et al.
Biochim Biophys Acta Gen Subj
. 2019 Sep;
1864(1):129433.
PMID: 31520681
Background: Kidney disease modeling and assessment of drug-induced kidney injury can be advanced using three-dimensional (3D) microfluidic models that recapitulate in vivo characteristics. Fluid shear stress (FSS) has been depicted...
6.
Nieskens T, Sjogren A
Semin Nephrol
. 2019 Mar;
39(2):215-226.
PMID: 30827343
Drug attrition related to kidney toxicity remains a challenge in drug discovery and development. In vitro models established over the past 2 decades to supplement in vivo studies have improved...
7.
Vormann M, Gijzen L, Hutter S, Boot L, Nicolas A, van den Heuvel A, et al.
AAPS J
. 2018 Aug;
20(5):90.
PMID: 30109442
Proximal tubules in the kidney play a crucial role in reabsorbing and eliminating substrates from the body into the urine, leading to high local concentrations of xenobiotics. This makes the...
8.
Vriend J, Nieskens T, Vormann M, van den Berge B, van den Heuvel A, Russel F, et al.
AAPS J
. 2018 Jul;
20(5):87.
PMID: 30051196
Drug-transporter interactions could impact renal drug clearance and should ideally be detected in early stages of drug development to avoid toxicity-related withdrawals in later stages. This requires reliable and robust...
9.
Nieskens T, Peters J, Dabaghie D, Korte D, Jansen K, Van Asbeck A, et al.
Drug Metab Dispos
. 2018 Mar;
46(5):592-599.
PMID: 29514829
Cisplatin is a cytostatic drug used for treatment of solid organ tumors. The main adverse effect is organic cation transporter 2 (OCT2)-mediated nephrotoxicity, observed in 30% of patients. The contribution...
10.
Nieskens T, Wilmer M
Eur J Pharmacol
. 2016 Jul;
790:46-56.
PMID: 27401035
The renal proximal tubule epithelium is responsible for active secretion of endogenous and exogenous waste products from the body and simultaneous reabsorption of vital compounds from the glomerular filtrate. The...