Janetta G Culvenor
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Explore the profile of Janetta G Culvenor including associated specialties, affiliations and a list of published articles.
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36
Citations
1072
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Recent Articles
1.
Mills R, Liang L, Lio D, Mok Y, Mulhern T, Cao G, et al.
J Neurochem
. 2018 Aug;
147(3):409-428.
PMID: 30091236
The Parkinson's disease (PD)-causative leucine-rich repeat kinase 2 (LRRK2) belongs to the Roco family of G-proteins comprising a Ras-of-complex (Roc) domain followed by a C-terminal of Roc (COR) domain in...
2.
Finkelstein D, Hare D, Billings J, Sedjahtera A, Nurjono M, Arthofer E, et al.
ACS Chem Neurosci
. 2015 Oct;
7(1):119-29.
PMID: 26481462
The abnormal accumulation of alpha-synuclein (α-syn) has been linked to a number of neurodegenerative disorders, the most noteworthy of which is Parkinson's disease. Alpha-synuclein itself is not toxic and fulfills...
3.
Mills R, Mulhern T, Liu F, Culvenor J, Cheng H
Hum Mutat
. 2014 Jan;
35(4):395-412.
PMID: 24470158
Genetic variations of leucine-rich repeat kinase 2 (LRRK2) are the major cause of dominantly inherited Parkinson disease (PD). LRRK2 protein contains seven predicted domains: a tandem Ras-like GTPase (ROC) domain...
4.
Mills R, Mulhern T, Cheng H, Culvenor J
Biochem Soc Trans
. 2012 Sep;
40(5):1086-9.
PMID: 22988870
Various investigators have identified the major domain organization of LRRK2 (leucine-rich repeat kinase 2), which includes a GTPase ROC (Ras of complex proteins) domain followed by a COR (C-terminal of...
5.
Sim C, Gabriel K, Mills R, Culvenor J, Cheng H
Hum Mutat
. 2012 May;
33(10):1408-22.
PMID: 22644621
Mutations of the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) gene can cause early-onset familial Parkinson disease (PD). PINK1 encodes a neuroprotective protein kinase localized at the mitochondria, and...
6.
Hung L, Villemagne V, Cheng L, Sherratt N, Ayton S, White A, et al.
J Exp Med
. 2012 Apr;
209(4):837-54.
PMID: 22473957
Parkinson's disease (PD) is a progressive, chronic disease characterized by dyskinesia, rigidity, instability, and tremors. The disease is defined by the presence of Lewy bodies, which primarily consist of aggregated...
7.
Soon C, Donnelly P, Turner B, Hung L, Crouch P, Sherratt N, et al.
J Biol Chem
. 2011 Oct;
286(51):44035-44044.
PMID: 22033929
Amyotrophic lateral sclerosis (ALS) is a progressive paralyzing disease characterized by tissue oxidative damage and motor neuron degeneration. This study investigated the in vivo effect of diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)), which...
8.
Ia K, Jeschke G, Deng Y, Aizuddin Kamaruddin M, Williamson N, Scanlon D, et al.
Biochemistry
. 2011 Jun;
50(31):6667-77.
PMID: 21699177
C-Terminal Src kinase-homologous kinase (CHK) exerts its tumor suppressor function by phosphorylating the C-terminal regulatory tyrosine of the Src-family kinases (SFKs). The phosphorylation suppresses their activity and oncogenic action. In...
9.
Silveyra M, Garcia-Ayllon M, Serra-Basante C, Mazzoni V, Garcia-Gutierrez M, Manzanares J, et al.
Neurobiol Aging
. 2011 May;
33(3):627.e27-37.
PMID: 21621296
We have previously identified presenilin-1 (PS1), the active component of the γ-secretase complex, as an interacting protein of the amyloid-associated enzyme acetylcholinesterase (AChE). In this study, we have explored the...
10.
Ho M, Hoke D, Chua Y, Li Q, Culvenor J, Masters C, et al.
Int J Alzheimers Dis
. 2011 Jan;
2011:950932.
PMID: 21253550
Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor protein (APP) at alternative sites to produce Aβ and the APP...