Janett Piesker
Overview
Explore the profile of Janett Piesker including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
192
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0
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Recent Articles
1.
Ruijmbeek C, Housley F, Idrees H, Housley M, Pestel J, Keller L, et al.
JCI Insight
. 2023 Aug;
8(17).
PMID: 37561591
Pediatric cardiomyopathy (CM) represents a group of rare, severe disorders that affect the myocardium. To date, the etiology and mechanisms underlying pediatric CM are incompletely understood, hampering accurate diagnosis and...
2.
Bensimon-Brito A, Boezio G, Cardeira-da-Silva J, Wietelmann A, Ramkumar S, Lundegaard P, et al.
Cardiovasc Res
. 2021 Oct;
118(12):2665-2687.
PMID: 34609500
Aims: Mammalian models have been instrumental in investigating adult heart function and human disease. However, electrophysiological differences with human hearts and high costs motivate the need for non-mammalian models. The...
3.
Gentile A, Bensimon-Brito A, Priya R, Maischein H, Piesker J, Guenther S, et al.
Elife
. 2021 Jun;
10.
PMID: 34152269
The transcription factor Snai1, a well-known regulator of epithelial-to-mesenchymal transition, has been implicated in early cardiac morphogenesis as well as in cardiac valve formation. However, a role for Snai1 in...
4.
Boezio G, Bensimon-Brito A, Piesker J, Guenther S, Helker C, Stainier D
Elife
. 2020 Sep;
9.
PMID: 32990594
The development of the cardiac outflow tract (OFT), which connects the heart to the great arteries, relies on a complex crosstalk between endothelial (ECs) and smooth muscle (SMCs) cells. Defects...
5.
Carlantoni C, Allanki S, Kontarakis Z, Rossi A, Piesker J, Gunther S, et al.
Dev Biol
. 2020 Sep;
469:54-67.
PMID: 32971120
Tie1 is a receptor tyrosine kinase expressed in endothelial cells, where it modulates Angiopoietin/Tie2 signaling. Previous studies have shown that mouse Tie1 mutants exhibit severe cardiovascular defects; however, much remains...
6.
Bensimon-Brito A, Ramkumar S, Boezio G, Guenther S, Kuenne C, Helker C, et al.
Dev Cell
. 2019 Dec;
52(1):9-20.e7.
PMID: 31786069
Cardiac valve disease can lead to severe cardiac dysfunction and is thus a frequent cause of morbidity and mortality. Its main treatment is valve replacement, which is currently greatly limited...
7.
Collins M, Ahlberg G, Hansen C, Guenther S, Marin-Juez R, Sokol A, et al.
Proc Natl Acad Sci U S A
. 2019 Nov;
116(48):24115-24121.
PMID: 31704768
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia. The major AF susceptibility locus 4q25 establishes long-range interactions with the promoter of , a transcription factor gene with...
8.
Stern D, Weisemann J, Le Blanc A, von Berg L, Mahrhold S, Piesker J, et al.
PLoS Pathog
. 2018 May;
14(5):e1007048.
PMID: 29718991
The exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. One peculiarity...
9.
Grossegesse M, Doellinger J, Fritsch A, Laue M, Piesker J, Schaade L, et al.
Sci Rep
. 2018 Jan;
8(1):1807.
PMID: 29379051
The emergence of Variola virus-like viruses by natural evolution of zoonotic Orthopoxviruses, like Cowpox virus (CPXV), is a global health threat. The proteasome is essential for poxvirus replication, making the...
10.
Stern D, Pauly D, Zydek M, Miller L, Piesker J, Laue M, et al.
PLoS One
. 2016 Mar;
11(3):e0150110.
PMID: 26930499
Orthopoxvirus species like cowpox, vaccinia and monkeypox virus cause zoonotic infections in humans worldwide. Infections often occur in rural areas lacking proper diagnostic infrastructure as exemplified by monkeypox, which is...