Janet R Sparrow
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Explore the profile of Janet R Sparrow including associated specialties, affiliations and a list of published articles.
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198
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5890
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Recent Articles
11.
Chang Y, Jenny L, Li Y, Cui X, Kong Y, Li Y, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(19):e2215005120.
PMID: 37126685
Genome-wide association studies (GWAS) have identified genetic risk loci for age-related macular degeneration (AMD) on the chromosome 10q26 (Chr10) locus and are tightly linked: the A69S (G>T) rs10490924 single-nucleotide variant...
12.
Greenstein V, Castillejos D, Tsang S, Lee W, Sparrow J, Allikmets R, et al.
Transl Vis Sci Technol
. 2023 May;
12(5):2.
PMID: 37126335
Purpose: To compare longitudinal changes in en face spectral domain-optical coherence tomography (SD-OCT) measurements of ellipsoid zone (EZ) and retinal pigment epithelium (RPE) loss to changes in the hypoautofluorescent and...
13.
Paavo M, Lee W, Parmann R, Lima de Carvalho Jr J, Zernant J, Tsang S, et al.
Invest Ophthalmol Vis Sci
. 2023 Apr;
64(4):27.
PMID: 37093133
Purpose: To describe the features of genetically confirmed PROM1-macular dystrophy in multimodal images. Methods: Thirty-six (36) eyes of 18 patients (5-66 years; mean age, 42.4 years) were prospectively studied by...
14.
Kong Y, Liu P, Li Y, Nolan N, Quinn P, Hsu C, et al.
EMBO Mol Med
. 2023 Jan;
15(2):e16525.
PMID: 36645044
Iron accumulation causes cell death and disrupts tissue functions, which necessitates chelation therapy to reduce iron overload. However, clinical utilization of deferoxamine (DFO), an iron chelator, has been documented to...
15.
Montenegro D, Zhao J, Kim H, Shmarakov I, Blaner W, Sparrow J
J Biol Chem
. 2022 Nov;
298(12):102722.
PMID: 36410431
Efficient delivery of vitamin A to the retinal pigment epithelium is vital to the production of the light-sensitive visual chromophore 11-cis-retinal. Nevertheless, retinol binding protein 4 (RBP4) is the only...
16.
Kolesnikova M, Lima de Carvalho Jr J, Parmann R, Kim A, Mahajan V, Tsang S, et al.
Mol Genet Genomic Med
. 2022 Oct;
10(11):e2038.
PMID: 36225124
Introduction: Leber congenital amaurosis (LCA) type 2, due to disease-causing variants in RPE65, is characterized by severe visual loss in early infancy. Current treatments include voretigene neparvovec-rzyl (VN) for RPE65-associated...
17.
Breazzano M, Oh J, Batson S, Kucherich J, Karani R, Rohrmann C, et al.
Eye (Lond)
. 2022 Jul;
37(7):1489-1495.
PMID: 35840717
Background: Spectral-domain optical coherence tomography (SD-OCT) and full-field electroretinography (ERG) allow retinal assessment with vitamin A deficiency (VAD). Using SD-OCT, this study aimed to characterize and follow a novel retinal...
18.
Parmann R, Greenstein V, Tsang S, Sparrow J
Invest Ophthalmol Vis Sci
. 2022 Jul;
63(8):4.
PMID: 35816046
Purpose: In choroideremia (CHM) carriers, scotopic sensitivity was assessed by dark adapted chromatic perimetry (DACP) and outer retinal structure was evaluated by multimodal imaging. Methods: Nine carriers (18 eyes) and...
19.
Kim H, Zhao J, Sparrow J
Redox Biol
. 2022 Jul;
54:102386.
PMID: 35809434
To facilitate the movement of retinoids through the visual cycle and to limit nonspecific chemical reaction, multiple mechanisms are utilized to handle these molecules when not contained within the binding...
20.
Verra D, Spinnhirny P, Sandu C, Gregoire S, Acar N, Berdeaux O, et al.
Graefes Arch Clin Exp Ophthalmol
. 2022 May;
260(10):3131-3148.
PMID: 35524799
Purpose: In many retinal pathological conditions, rod and cone degeneration differs. For example, the early-onset maculopathy Stargardts disease type 1 (STGD1) is typified by loss of cones while rods are...