Janet M Wenzlau
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Explore the profile of Janet M Wenzlau including associated specialties, affiliations and a list of published articles.
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31
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1176
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Recent Articles
1.
Jia X, Wenzlau J, Zhang C, Dong F, Waugh K, Leslie R, et al.
Diabetes
. 2025 Jan;
PMID: 39821270
Increasing evidence shows that pathogenic T cells in type 1 diabetes (T1D) that may have evaded negative selection recognize post-translational modified (PTM) epitopes of self-antigens. We have investigated the profiles...
2.
Wenzlau J, Peterson O, Vomund A, DiLisio J, Hohenstein A, Haskins K, et al.
Front Immunol
. 2024 Mar;
15:1348131.
PMID: 38455055
There is accumulating evidence that pathogenic T cells in T1D recognize epitopes formed by post-translational modifications of β-cell antigens, including hybrid insulin peptides (HIPs). The ligands for several CD4 T-cell...
3.
Wenzlau J, Gu Y, Michels A, Rewers M, Haskins K, Yu L
Diagnostics (Basel)
. 2023 Sep;
13(17).
PMID: 37685398
Type 1 diabetes (T1D) is a chronic autoimmune disease that attacks the insulin-producing b cells of the pancreatic islets. Autoantibodies to b cell proteins typically appear in the circulation years...
4.
Crawford S, Wiles T, Wenzlau J, Powell R, Barbour G, Dang M, et al.
Diabetes
. 2022 Aug;
71(12):2793-2803.
PMID: 36041196
Hybrid insulin peptides (HIPs) form in pancreatic β-cells through the formation of peptide bonds between proinsulin fragments and other peptides. HIPs have been identified in pancreatic islets by mass spectrometry...
5.
Wenzlau J, DiLisio J, Barbour G, Dang M, Hohenstein A, Nakayama M, et al.
Front Immunol
. 2022 Aug;
13:926650.
PMID: 36032090
Insulin is considered to be a key antigenic target of T cells in Type 1 Diabetes (T1D) and autoimmune diabetes in the NOD mouse with particular focus on the B-chain...
6.
Lahner E, Marzinotto I, Lampasona V, Dottori L, Bazzigaluppi E, Brigatti C, et al.
Clin Transl Gastroenterol
. 2020 Oct;
11(10):e00240.
PMID: 33031196
Introduction: Noninvasive assessment of corpus atrophic gastritis (CAG), a condition at increased risk of gastric cancer, is based on the measurement of pepsinogens, gastrin, and Helicobacter pylori antibodies. Parietal cell...
7.
Lahner E, Brigatti C, Marzinotto I, Carabotti M, Scalese G, Davidson H, et al.
Clin Transl Gastroenterol
. 2017 Jan;
8(1):e215.
PMID: 28102858
Objectives: Circulating autoantibodies targeting the H+/K+-ATPase proton pump of gastric parietal cells are considered markers of autoimmune gastritis, whose diagnostic accuracy in atrophic body gastritis, the pathological lesion of autoimmune...
8.
Wenzlau J, Fain P, Gardner T, Frisch L, Annibale B, Hutton J
Diabetes Care
. 2015 Sep;
38 Suppl 2:S29-36.
PMID: 26405069
Autoantibodies targeting the H+/K+-ATPase proton pump of the gastric parietal cell (parietal cell antibodies [PCA]) are diagnostic of atrophic body gastritis (ABG) leading to pernicious anemia (PA). PCA, ABG, and...
9.
Wenzlau J, Frisch L, Hutton J, Fain P, Davidson H
Diabetes Care
. 2015 Sep;
38 Suppl 2:S14-20.
PMID: 26405067
Zinc transporter 8 autoantibodies (ZnT8A) were analyzed in sera from 1,504 subjects as part of the Type 1 Diabetes Genetics Consortium (T1DGC) Autoantibody Workshop. For these participants with type 1...
10.
Demeester S, Keymeulen B, Kaufman L, Van Dalem A, Balti E, Van de Velde U, et al.
Diabetes Care
. 2015 Jan;
38(4):644-51.
PMID: 25583753
Objective: Immune intervention trials in recent-onset type 1 diabetes would benefit from biomarkers associated with good therapeutic response. In the previously reported randomized placebo-controlled anti-CD3 study (otelixizumab; GlaxoSmithKline), we tested...