George S Eisenbarth
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Explore the profile of George S Eisenbarth including associated specialties, affiliations and a list of published articles.
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193
Citations
8797
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Recent Articles
1.
Pugliese A, Boulware D, Yu L, Babu S, Steck A, Becker D, et al.
Diabetes
. 2016 Jan;
65(4):1109-19.
PMID: 26822082
The HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype is linked to protection from the development of type 1 diabetes (T1D). However, it is not known at which stages in the natural history of T1D development...
2.
Brorsson C, Onengut S, Chen W, Wenzlau J, Yu L, Baker P, et al.
Diabetes
. 2015 Apr;
64(8):3017-27.
PMID: 25829454
Islet autoantibodies detected at disease onset in patients with type 1 diabetes are signs of an autoimmune destruction of the insulin-producing β-cells. To further investigate the genetic determinants of autoantibody...
3.
Liu E, Lee H, Aronsson C, Hagopian W, Koletzko S, Rewers M, et al.
N Engl J Med
. 2014 Jul;
371(1):42-9.
PMID: 24988556
Background: The presence of HLA haplotype DR3-DQ2 or DR4-DQ8 is associated with an increased risk of celiac disease. In addition, nearly all children with celiac disease have serum antibodies against...
4.
γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation
Aydintug M, Zhang L, Wang C, Liang D, Wands J, Michels A, et al.
Mol Immunol
. 2014 May;
60(2):116-28.
PMID: 24853397
The insulin peptide B:9-23 is a natural antigen in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D). In addition to αβ T cells and B cells, γδ...
5.
Zhang L, Londono P, Yu L, Grimes S, Blackburn P, Gottlieb P, et al.
Autoimmunity
. 2014 May;
47(5):341-50.
PMID: 24783965
MAS-1, a nanoparticular, emulsion-based adjuvant, was evaluated for its ability to promote Th2 and regulatory immune responses and prevent type 1 diabetes progression when given alone or as antigen-specific immunotherapy...
6.
Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson H, et al.
Proc Natl Acad Sci U S A
. 2014 Feb;
111(7):2656-61.
PMID: 24550292
The primary autoantigen triggering spontaneous type 1 diabetes mellitus in nonobese diabetic (NOD) mice is insulin. The major T-cell insulin epitope lies within the amino acid 9-23 peptide of the...
7.
Miao D, Guyer K, Dong F, Jiang L, Steck A, Rewers M, et al.
Diabetes
. 2013 Aug;
62(12):4174-8.
PMID: 23974918
The identification of diabetes-relevant islet autoantibodies is essential for predicting and preventing type 1 diabetes (T1D). The aim of the current study was to evaluate a newly developed electrochemiluminescence (ECL)-GAD...
8.
Atkinson M, Eisenbarth G, Michels A
Lancet
. 2013 Jul;
383(9911):69-82.
PMID: 23890997
Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology....
9.
Frederiksen B, Kroehl M, Lamb M, Seifert J, Barriga K, Eisenbarth G, et al.
JAMA Pediatr
. 2013 Jul;
167(9):808-15.
PMID: 23836309
Importance: The incidence of type 1 diabetes mellitus (T1DM) is increasing worldwide, with the most rapid increase among children younger than 5 years of age. Objective: To examine the associations...
10.
Roep B, Solvason N, Gottlieb P, Abreu J, Harrison L, Eisenbarth G, et al.
Sci Transl Med
. 2013 Jun;
5(191):191ra82.
PMID: 23803704
In type 1 diabetes (T1D), there is an intense inflammatory response that destroys the β cells in the pancreatic islets of Langerhans, the site where insulin is produced and released....