Janelle M Spinazzola
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Explore the profile of Janelle M Spinazzola including associated specialties, affiliations and a list of published articles.
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13
Citations
309
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Recent Articles
1.
Lek A, Wong B, Keeler A, Blackwood M, Ma K, Huang S, et al.
N Engl J Med
. 2023 Sep;
389(13):1203-1210.
PMID: 37754285
We treated a 27-year-old patient with Duchenne's muscular dystrophy (DMD) with recombinant adeno-associated virus (rAAV) serotype 9 containing dCas9 (i.e., "dead" Cas9, in which the Cas9 nuclease activity has been...
2.
Lambert M, Spinazzola J, Widrick J, Pakula A, Conner J, Chin J, et al.
Mol Ther
. 2020 Nov;
29(3):1086-1101.
PMID: 33221436
Duchenne muscular dystrophy (DMD) is a severe genetic disorder caused by mutations in the DMD gene. Absence of dystrophin protein leads to progressive degradation of skeletal and cardiac function and...
3.
Spinazzola J, Lambert M, Gibbs D, Conner J, Krikorian G, Pareek P, et al.
Biol Open
. 2020 Jul;
9(8).
PMID: 32718931
Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease caused by mutation of the gene. Pharmacological therapies that function independently of dystrophin and complement strategies aimed at dystrophin restoration could...
4.
Pakula A, Spinazzola J, Gussoni E
Methods Mol Biol
. 2018 Oct;
1889:1-15.
PMID: 30367405
Primary myoblasts derived from human tissue are a valuable tool in research of muscle disease and pathophysiology. However, skeletal muscle biopsies, especially from diseased muscle, contain a plethora of non-myogenic...
5.
Spinazzola J, Gussoni E
Bio Protoc
. 2017 Nov;
7(21).
PMID: 29152538
Primary myoblast culture is a valuable tool in research of muscle disease, pathophysiology, and pharmacology. This protocol describes techniques for dissociation of cells from human skeletal muscle biopsies and enrichment...
6.
Spinazzola J, Kunkel L
Expert Opin Orphan Drugs
. 2017 Jul;
4(11):1179-1194.
PMID: 28670506
Introduction: Since the identification of the dystrophin gene in 1986, a cure for Duchenne muscular dystrophy (DMD) has yet to be discovered. Presently, there are a number of genetic-based therapies...
7.
Vieira N, Spinazzola J, Alexander M, Moreira Y, Kawahara G, Gibbs D, et al.
Proc Natl Acad Sci U S A
. 2017 May;
114(23):6080-6085.
PMID: 28533404
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease caused by X-linked inherited mutations in the () gene. Absence of dystrophin protein from the sarcolemma causes severe muscle degeneration,...
8.
Spinazzola J, Gussoni E
Cell Stem Cell
. 2017 Jan;
20(1):1-3.
PMID: 28061348
Exosome-dependent intercellular communication is an emerging signaling mechanism involved in tissue repair and regeneration. Now in this issue of Cell Stem Cell, Fry et al. (2016) show that muscle stem...
9.
Alexander M, Rozkalne A, Colletta A, Spinazzola J, Johnson S, Rahimov F, et al.
Cell Stem Cell
. 2016 Sep;
19(6):800-807.
PMID: 27641304
Cell-surface markers for prospective isolation of stem cells from human skeletal muscle have been difficult to identify. Such markers would be powerful tools for studying satellite cell function during homeostasis...
10.
Philippou A, Minozzo F, Spinazzola J, Smith L, Lei H, Rassier D, et al.
FASEB J
. 2015 Mar;
29(7):2769-79.
PMID: 25795455
Muscle loading is important for maintaining muscle mass; when load is removed, atrophy is inevitable. However, in clinical situations such as critical care myopathy, masticatory muscles do not lose mass....