Matthew S Alexander
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Explore the profile of Matthew S Alexander including associated specialties, affiliations and a list of published articles.
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66
Citations
1403
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Recent Articles
1.
Huang L, Simonian R, Lopez M, Karuppasamy M, Sanders V, English K, et al.
EMBO Mol Med
. 2025 Feb;
PMID: 39994482
X-linked myopathy with excessive autophagy (XMEA), a rare childhood-onset autophagic vacuolar myopathy caused by mutations in VMA21, is characterized by proximal muscle weakness and progressive vacuolation. VMA21 encodes a protein...
2.
Karuppasamy M, English K, Conner J, Rorrer S, Lopez M, Crossman D, et al.
bioRxiv
. 2025 Feb;
PMID: 39975305
Duchenne muscular dystrophy (DMD) patients suffer from skeletal and cardiopulmonary weakness, and interestingly up to one third are diagnosed on the autism spectrum. Dystrophin is an essential protein for regulating...
3.
Alexander M, Robin N
Curr Opin Pediatr
. 2024 Sep;
36(6):619-623.
PMID: 39297696
Purpose Of Review: A growing number of gene therapies are getting FDA-approved for pediatric rare disorders to treat once incurable diseases. Opportunities for preventing lifetime illness and improving quality of...
4.
Heitman K, Bollenbecker S, Bradley J, Czaya B, Fajol A, Thomas S, et al.
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273260
Chronic kidney disease (CKD) is associated with various pathologic changes, including elevations in serum phosphate levels (hyperphosphatemia), vascular calcification, and skeletal muscle atrophy. Elevated phosphate can damage vascular smooth muscle...
5.
Heitman K, Alexander M, Faul C
Int J Mol Sci
. 2024 May;
25(10).
PMID: 38791164
Chronic kidney disease (CKD) is associated with significant reductions in lean body mass and in the mass of various tissues, including skeletal muscle, which causes fatigue and contributes to high...
6.
Sothers H, Hu X, Crossman D, Si Y, Alexander M, McDonald M, et al.
bioRxiv
. 2024 May;
PMID: 38712206
Duchenne muscular dystrophy (DMD) is a fatal X-linked recessive disease due to loss-of-function mutations in the gene. DMD-related skeletal muscle wasting is typified by an aberrant immune response involving upregulation...
7.
Tam C, Alexander M, Sanderson J, Qi S
Med Eng Phys
. 2024 Feb;
124:104110.
PMID: 38418021
Drug-eluting contact lenses (DECLs) incorporated with poly(lactic-co-glycolic acid) (PLGA) and various model drugs (ketotifen fumarate, bimatoprost and latanoprost) were fabricated using nanoelectrospray (nES) approach. The resulting DECLs demonstrated outstanding optical...
8.
Karuppasamy M, English K, Henry C, Manzini M, Parant J, Wright M, et al.
Dis Model Mech
. 2024 Jan;
17(1).
PMID: 38235578
Skeletal muscular diseases predominantly affect skeletal and cardiac muscle, resulting in muscle weakness, impaired respiratory function and decreased lifespan. These harmful outcomes lead to poor health-related quality of life and...
9.
Alexander M, Velinov M
Genes (Basel)
. 2023 Oct;
14(10).
PMID: 37895289
The protein product of is highly expressed in neurons and has a role in cell adhesion and neuronal outgrowth through its interaction with the actin cytoskeleton and key cell signaling...
10.
Samani A, Karuppasamy M, English K, Siler C, Wang Y, Widrick J, et al.
FASEB J
. 2023 Sep;
37(10):e23198.
PMID: 37742307
DOCK (dedicator of cytokinesis) is an 11-member family of typical guanine nucleotide exchange factors (GEFs) expressed in the brain, spinal cord, and skeletal muscle. Several DOCK proteins have been implicated...