Jane V Harper
Overview
Explore the profile of Jane V Harper including associated specialties, affiliations and a list of published articles.
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12
Citations
1020
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Recent Articles
1.
van den Berg J, Gomez-Eerland R, van de Wiel B, Hulshoff L, van den Broek D, Bins A, et al.
Mol Ther
. 2015 Apr;
23(9):1541-50.
PMID: 25896248
Here, we describe a fatal serious adverse event observed in a patient infused with autologous T-cell receptor (TCR) transduced T cells. This TCR, originally obtained from a melanoma patient, recognizes...
2.
Cameron B, Gerry A, Dukes J, Harper J, Kannan V, Bianchi F, et al.
Sci Transl Med
. 2013 Aug;
5(197):197ra103.
PMID: 23926201
MAGE A3, which belongs to the family of cancer-testis antigens, is an attractive target for adoptive therapy given its reactivation in various tumors and limited expression in normal tissues. We...
3.
Reynolds P, Anderson J, Harper J, Hill M, Botchway S, Parker A, et al.
Nucleic Acids Res
. 2012 Sep;
40(21):10821-31.
PMID: 23012265
DNA double-strand breaks (DSBs) are biologically one of the most important cellular lesions and possess varying degrees of chemical complexity. The notion that the repairability of more chemically complex DSBs...
4.
Liddy N, Bossi G, Adams K, Lissina A, Mahon T, Hassan N, et al.
Nat Med
. 2012 May;
18(6):980-7.
PMID: 22561687
T cell immunity can potentially eradicate malignant cells and lead to clinical remission in a minority of patients with cancer. In the majority of these individuals, however, there is a...
5.
Anderson J, Harper J, Cucinotta F, ONeill P
Radiat Res
. 2010 Aug;
174(2):195-205.
PMID: 20681786
Cellular lesions (e.g. DSBs) are induced into DNA upon exposure to radiation, with DSB complexity increasing with radiation ionization density. Using M059K and M059J human glioblastoma cells (proficient and deficient...
6.
Harper J, Anderson J, ONeill P
DNA Repair (Amst)
. 2010 Jul;
9(8):907-13.
PMID: 20634148
When cells are exposed to radiation serious lesions are introduced into the DNA including double strand breaks (DSBs), single strand breaks (SSBs), base modifications and clustered damage sites (a specific...
7.
Harper J, Reynolds P, Leatherbarrow E, Botchway S, Parker A, ONeill P
Photochem Photobiol
. 2008 Jun;
84(6):1506-14.
PMID: 18557822
DNA double strand breaks (DSBs) are amongst the most deleterious lesions induced within the cell following exposure to ionizing radiation. Mammalian cells repair these breaks predominantly via the nonhomologous end...
8.
Cucinotta F, Pluth J, Anderson J, Harper J, ONeill P
Radiat Res
. 2008 Jan;
169(2):214-22.
PMID: 18220463
We developed a biochemical kinetics approach to describe the repair of double-strand breaks (DSBs) produced by low-LET radiation by modeling molecular events associated with non-homologous end joining (NHEJ). A system...
9.
Leatherbarrow E, Harper J, Cucinotta F, ONeill P
Int J Radiat Biol
. 2006 Mar;
82(2):111-8.
PMID: 16546909
Purpose: To investigate quantitatively the induction and rejoining of DNA double strand breaks (DSB) in V79-4 and xrs-5 Chinese hamster cells and HF19 human fibroblast cells, using the phosphorylation of...
10.
Harper J
Methods Mol Biol
. 2004 Dec;
296:157-66.
PMID: 15576930
The method described in the following chapter utilizes a double thymidine block (an inhibitor of DNA synthesis) followed by treatment of cells with nocodazole (a mitotic inhibitor) to obtain large...