Jana Kusch
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Explore the profile of Jana Kusch including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
495
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Recent Articles
1.
Benndorf K, Enke U, Tewari D, Kusch J, Liu H, Sun H, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(5):e2422533122.
PMID: 39879240
In mammals, the four subunit isoforms HCN1-4 assemble to form functional homotetrameric and heterotetrameric hyperpolarization-activated cyclic nucleotide-modulated (HCN) ion channels. Despite the outstanding relevance of HCN channels for organisms, including...
2.
Porro A, Saponaro A, Castelli R, Introini B, Hafez Alkotob A, Ranjbari G, et al.
Nat Commun
. 2024 Jan;
15(1):843.
PMID: 38287019
Binding of cAMP to Hyperpolarization activated cyclic nucleotide gated (HCN) channels facilitates pore opening. It is unclear why the isolated cyclic nucleotide binding domain (CNBD) displays in vitro lower affinity...
3.
Yuksel S, Bonus M, Schwabe T, Pfleger C, Zimmer T, Enke U, et al.
Front Physiol
. 2022 Sep;
13:895324.
PMID: 36091400
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetramers that generate electrical rhythmicity in special brain neurons and cardiomyocytes. The channels are activated by membrane hyperpolarization. The binding of cAMP to the...
4.
Kondapuram M, Frieg B, Yuksel S, Schwabe T, Sattler C, Lelle M, et al.
Commun Biol
. 2022 May;
5(1):430.
PMID: 35534535
Hyperpolarization-activated and cyclic nucleotide (HCN) modulated channels are tetrameric cation channels. In each of the four subunits, the intracellular cyclic nucleotide-binding domain (CNBD) is coupled to the transmembrane domain via...
5.
Lehmann J, Jorgensen M, Fratz S, Muller H, Kusch J, Scherzer S, et al.
Curr Biol
. 2021 Jul;
31(16):3575-3585.e9.
PMID: 34233161
Plants, as sessile organisms, gained the ability to sense and respond to biotic and abiotic stressors to survive severe changes in their environments. The change in our climate comes with...
6.
Pfleger C, Kusch J, Kondapuram M, Schwabe T, Sattler C, Benndorf K, et al.
Biophys J
. 2021 Jan;
120(5):950-963.
PMID: 33515603
Opening of hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels is controlled by membrane hyperpolarization and binding of cyclic nucleotides to the tetrameric cyclic nucleotide-binding domain (CNBD), attached to the C-linker (CL) disk....
7.
Leypold T, Bonus M, Spiegelhalter F, Schwede F, Schwabe T, Gohlke H, et al.
J Biol Chem
. 2019 Oct;
294(47):17978-17987.
PMID: 31615893
cAMP acts as a second messenger in many cellular processes. Three protein types mainly mediate cAMP-induced effects: PKA, exchange protein directly activated by cAMP (Epac), and cyclic nucleotide-modulated channels (cyclic...
8.
Ando T, Bhamidimarri S, Brending N, Colin-York H, Collinson L, de Jonge N, et al.
J Phys D Appl Phys
. 2019 Feb;
51(44):443001.
PMID: 30799880
Developments in microscopy have been instrumental to progress in the life sciences, and many new techniques have been introduced and led to new discoveries throughout the last century. A wide...
9.
Sunkara M, Schwabe T, Ehrlich G, Kusch J, Benndorf K
J Gen Physiol
. 2018 Jul;
150(9):1261-1271.
PMID: 29959170
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetramers that elicit electrical rhythmicity in specialized brain neurons and cardiomyocytes. The channels are dually activated by voltage and binding of cyclic adenosine monophosphate...
10.
Nache V, Wongsamitkul N, Kusch J, Zimmer T, Schwede F, Benndorf K
Sci Rep
. 2018 Jun;
8:47000.
PMID: 29952375
This corrects the article DOI: 10.1038/srep29378.