Jan Zitko
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Explore the profile of Jan Zitko including associated specialties, affiliations and a list of published articles.
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Citations
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Recent Articles
11.
Juhas M, Pallabothula V, Grabrijan K, Simovicova M, Jandourek O, Konecna K, et al.
Bioorg Chem
. 2021 Nov;
118:105489.
PMID: 34826708
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is the number one cause of deaths due to a single infectious agent worldwide. The treatment of TB is lengthy and often complicated...
12.
Bouz G, Bouz S, Jandourek O, Konecna K, Barta P, Vinsova J, et al.
Pharmaceuticals (Basel)
. 2021 Aug;
14(8).
PMID: 34451864
Despite the established treatment regimens, tuberculosis remains an alarming threat to public health according to WHO. Novel agents are needed to overcome the increasing rate of resistance and perhaps achieve...
13.
Pang L, Weeks S, Juhas M, Strelkov S, Zitko J, Van Aerschot A
Int J Mol Sci
. 2021 Aug;
22(15).
PMID: 34360555
Human cytosolic prolyl-tRNA synthetase (HcProRS) catalyses the formation of the prolyl-tRNA, playing an important role in protein synthesis. Inhibition of HcProRS activity has been shown to have potential benefits in...
14.
Bouz G, Zitko J
Bioorg Chem
. 2021 Apr;
110:104806.
PMID: 33799176
Aminoacyl-tRNA synthetases (aaRSs) are crucial for the correct assembly of amino acids to cognate tRNA to maintain the fidelity of proteosynthesis. AaRSs have become a hot target in antimicrobial research....
15.
Nawrot D, Suchankova E, Jandourek O, Konecna K, Barta P, Dolezal M, et al.
Chem Biol Drug Des
. 2020 Oct;
97(3):686-700.
PMID: 33068457
A series of N-pyridinylbenzamides was designed and prepared to investigate the influence of isosterism and positional isomerism on antimycobacterial activity. Comparison to previously published isosteric N-pyrazinylbenzamides was made as an...
16.
Juhas M, Zitko J
J Med Chem
. 2020 Apr;
63(17):8901-8916.
PMID: 32275822
Pyrazine-based compounds are of great importance in medicinal chemistry. Due to their heteroaromatic nature, they uniquely combine properties of heteroatoms (polar interactions) with the properties of aromatic moieties (nonpolar interactions)....
17.
Ambrozkiewicz W, Kucerova-Chlupacova M, Jandourek O, Konecna K, Paterova P, Barta P, et al.
Molecules
. 2020 Apr;
25(7).
PMID: 32231166
According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year....
18.
Juhas M, Kucerova L, Horacek O, Jandourek O, Kubicek V, Konecna K, et al.
Molecules
. 2020 Apr;
25(7).
PMID: 32230728
Tuberculosis is an infectious disease caused by (Mtb), each year causing millions of deaths. In this article, we present the synthesis and biological evaluations of new potential antimycobacterial compounds containing...
19.
Bouz G, Juhas M, Pausas Otero L, Paredes de la Red C, Jandourek O, Konecna K, et al.
Molecules
. 2020 Jan;
25(1).
PMID: 31905775
We prepared a series of substituted -(pyrazin-2-yl)benzenesulfonamides as an attempt to investigate the effect of different linkers connecting pyrazine to benzene cores on antimicrobial activity when compared to our previous...
20.
Beegum S, Sheena Mary Y, Mary Y, Thomas R, Armakovic S, Armakovic S, et al.
Spectrochim Acta A Mol Biomol Spectrosc
. 2019 Aug;
224:117414.
PMID: 31376725
This article represents the spectroscopic and computational studies of two new pyrazine compounds. In order to establish the structure and functional nature of the compounds, we have employed Fourier transformed...