Jan van Riggelen
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Explore the profile of Jan van Riggelen including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Choi P, van Riggelen J, Gentles A, Bachireddy P, Rakhra K, Adam S, et al.
Proc Natl Acad Sci U S A
. 2011 Oct;
108(42):17432-7.
PMID: 21969595
The suppression of oncogenic levels of MYC is sufficient to induce sustained tumor regression associated with proliferative arrest, differentiation, cellular senescence, and/or apoptosis, a phenomenon known as oncogene addiction. However,...
12.
Muller J, Samans B, van Riggelen J, Faga G, Peh K N R, Wei C, et al.
Cell Cycle
. 2010 Dec;
9(23):4622-6.
PMID: 21127397
Deregulated expression of Myc under the control of an immunoglobulin enhancer induces lymphoma formation in mice. The development of lymphomas is limited by TGFβ-dependent senescence and high levels of Myc...
13.
van Riggelen J, Muller J, Otto T, Beuger V, Yetil A, Choi P, et al.
Genes Dev
. 2010 Jun;
24(12):1281-94.
PMID: 20551174
The Myc protein suppresses the transcription of several cyclin-dependent kinase inhibitors (CKIs) via binding to Miz1; whether this interaction is important for Myc's ability to induce or maintain tumorigenesis is...
14.
van Riggelen J, Yetil A, Felsher D
Nat Rev Cancer
. 2010 Mar;
10(4):301-9.
PMID: 20332779
MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also...
15.
van Riggelen J, Felsher D
Nat Cell Biol
. 2009 Dec;
12(1):7-9.
PMID: 20027199
Cdk2 has been shown to have an unanticipated role in suppressing Myc-induced senescence. This has implications for how c-Myc overcomes failsafe mechanisms to induce tumorigenesis and suggests that the inhibition...
16.
Wu C, van Riggelen J, Yetil A, Fan A, Bachireddy P, Felsher D
Proc Natl Acad Sci U S A
. 2007 Aug;
104(32):13028-33.
PMID: 17664422
Oncogene-induced senescence is an important mechanism by which normal cells are restrained from malignant transformation. Here we report that the suppression of the c-Myc (MYC) oncogene induces cellular senescence in...
17.
Giuriato S, Ryeom S, Fan A, Bachireddy P, Lynch R, Rioth M, et al.
Proc Natl Acad Sci U S A
. 2006 Oct;
103(44):16266-71.
PMID: 17056717
The targeted inactivation of oncogenes offers a rational therapeutic approach for the treatment of cancer. However, the therapeutic inactivation of a single oncogene has been associated with tumor recurrence. Therefore,...
18.
van Riggelen J, Buchwalter G, Soto U, De-Castro Arce J, Zur Hausen H, Wasylyk B, et al.
J Biol Chem
. 2004 Nov;
280(5):3286-94.
PMID: 15548518
We have investigated the expression of c-fos in cervical carcinoma cells and in somatic cell hybrids derived therefrom. In malignant cells, c-fos was constitutively expressed even after serum starvation. Dissection...
19.
De-Castro Arce J, Soto U, van Riggelen J, Schwarz E, Zur Hausen H, Rosl F
J Biol Chem
. 2004 Aug;
279(44):45408-16.
PMID: 15308638
Expression of the nuclear retinoic acid receptor beta2 (RARbeta2) gene is often disturbed in cervical carcinoma cells. One important mechanism by which RARbeta2 can exert growth inhibitory function is based...
20.
Bachmann A, Hanke B, Zawatzky R, Soto U, van Riggelen J, Zur Hausen H, et al.
J Virol
. 2001 Dec;
76(1):280-91.
PMID: 11739693
In the present study we show that malignant human papillomavirus (HPV)-positive cells lost their ability to synthesize endogenous beta interferon (IFN-beta) upon tumor necrosis factor alpha (TNF-alpha) treatment. IFN-beta transcription,...