Jan Schlegel
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Explore the profile of Jan Schlegel including associated specialties, affiliations and a list of published articles.
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24
Citations
233
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Recent Articles
1.
Carravilla P, Andronico L, Schlegel J, Urem Y, Sjule E, Ragaller F, et al.
Nat Protoc
. 2025 Feb;
PMID: 39972239
Membrane fluidity is a crucial parameter for cellular physiology. Recent evidence suggests that fluidity varies between cell types and states and in diseases. As membrane fluidity has gradually become an...
2.
Doktorova M, Symons J, Zhang X, Wang H, Schlegel J, Lorent J, et al.
bioRxiv
. 2024 Dec;
PMID: 39713443
Membranes are molecular interfaces that compartmentalize cells to control the flow of nutrients and information. These functions are facilitated by diverse collections of lipids, nearly all of which are distributed...
3.
Weber F, Iskrak S, Ragaller F, Schlegel J, Plochberger B, Sezgin E, et al.
J Cell Sci
. 2024 Sep;
137(20).
PMID: 39258319
Environment-sensitive probes are frequently used in spectral and multi-channel microscopy to study alterations in cell homeostasis. However, the few open-source packages available for processing of spectral images are limited in...
4.
Porebski B, Christ W, Corman A, Haraldsson M, Barz M, Lidemalm L, et al.
Mol Ther
. 2024 Jul;
32(9):3012-3024.
PMID: 38956870
Several viruses hijack various forms of endocytosis in order to infect host cells. Here, we report the discovery of a molecule with antiviral properties that we named virapinib, which limits...
5.
Klein T, Gruner J, Breyer M, Schlegel J, Schottmann N, Hofmann L, et al.
Brain Commun
. 2024 Apr;
6(2):fcae095.
PMID: 38638148
Acral burning pain triggered by fever, thermal hyposensitivity and skin denervation are hallmarks of small fibre neuropathy in Fabry disease, a life-threatening X-linked lysosomal storage disorder. Variants in the gene...
6.
Ragaller F, Sjule E, Urem Y, Schlegel J, El R, Urbancic D, et al.
J Phys Chem B
. 2024 Feb;
128(9):2154-2167.
PMID: 38415644
The structural diversity of different lipid species within the membrane defines its biophysical properties such as membrane fluidity, phase transition, curvature, charge distribution, and tension. Environment-sensitive probes, which change their...
7.
Sych T, Schlegel J, Barriga H, Ojansivu M, Hanke L, Weber F, et al.
Nat Biotechnol
. 2023 Jun;
42(4):587-590.
PMID: 37308687
We introduce a method, single-particle profiler, that provides single-particle information on the content and biophysical properties of thousands of particles in the size range 5-200 nm. We use our single-particle...
8.
Brenner D, Geiger N, Schlegel J, Diesendorf V, Kersting L, Fink J, et al.
Int J Mol Sci
. 2023 Apr;
24(8).
PMID: 37108461
Recently, we have shown that C6-ceramides efficiently suppress viral replication by trapping the virus in lysosomes. Here, we use antiviral assays to evaluate a synthetic ceramide derivative α-NH2-ω-N3-C6-ceramide (AKS461) and...
9.
Schlegel J, Porebski B, Andronico L, Hanke L, Edwards S, Brismar H, et al.
Nano Lett
. 2023 Mar;
23(9):3701-3707.
PMID: 36892970
Speed is key during infectious disease outbreaks. It is essential, for example, to identify critical host binding factors to pathogens as fast as possible. The complexity of host plasma membrane...
10.
Sternstein C, Schlegel J, Sauer M, Seibel J
J Lipid Res
. 2022 Nov;
64(1):100311.
PMID: 36370806
No abstract available.