Jan Rossaint
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Explore the profile of Jan Rossaint including associated specialties, affiliations and a list of published articles.
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85
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3544
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Recent Articles
1.
Poti F, Scalera E, Feuerborn R, Fischer J, Arndt L, Varga G, et al.
JCI Insight
. 2024 Nov;
9(24).
PMID: 39531328
Sphingosine 1-phosphate (S1P) is a lysosphingolipid with antiatherogenic properties, but mechanisms underlying its effects remain unclear. We here investigated atherosclerosis development in cholesterol-rich diet-fed LDL receptor-deficient mice with high or...
2.
Hellenthal K, Thomas K, Ludwig N, Cappenberg A, Schemmelmann L, Tekath T, et al.
J Leukoc Biol
. 2024 Nov;
PMID: 39504570
During sterile inflammation, tissue damage induces excessive activation and infiltration of neutrophils into tissues, where they critically contribute to organ dysfunction. Tight regulation of neutrophil migration and their effector functions...
3.
Goretzko J, Pauels I, Heitzig N, Thomas K, Kardell M, Nass J, et al.
Cell Rep
. 2023 Dec;
42(12):113501.
PMID: 38039128
Upon proinflammatory challenges, endothelial cell surface presentation of the leukocyte receptor P-selectin, together with the stabilizing co-factor CD63, is needed for leukocyte capture and is mediated via demand-driven exocytosis from...
4.
Liu C, Gorlich D, Lowell C, Italiano J, Rossaint J, Bender M, et al.
Clin Chem Lab Med
. 2023 Dec;
62(5):999-1010.
PMID: 38037809
Objectives: Sepsis is a life-threatening condition implicating an inadequate activation of the immune system. Platelets act as modulators and contributors to immune processes. Indeed, altered platelet turnover, thrombotic events, and...
5.
Ludwig N, Thorner-van Almsick J, Mersmann S, Bardel B, Niemann S, Chasan A, et al.
Front Immunol
. 2023 Oct;
14:1259004.
PMID: 37849760
is a common cause of hospital-acquired pneumonia associated with high mortality. Adequate clinical treatment is impeded by increasing occurrence of antibiotic resistances. Understanding the underlying mechanisms of its virulence during...
6.
Hosseinnejad A, Ludwig N, Mersmann S, Winnerbach P, Bleilevens C, Rossaint R, et al.
Small
. 2023 Jan;
19(14):e2205185.
PMID: 36635040
Nitric oxide (NO) plays a significant role in controlling the physiology and pathophysiology of the body, including the endothelial antiplatelet function and therefore, antithrombogenic property of the blood vessels. This...
7.
Revenstorff J, Ludwig N, Hilger A, Mersmann S, Lehmann M, Grenzheuser J, et al.
Cells
. 2022 Dec;
11(23).
PMID: 36497202
Acute respiratory distress syndrome (ARDS) due to pulmonary infections is associated with high morbidity and mortality. Upon inflammation, the alarmin S100A8/A9 is released and stimulates neutrophil recruitment mainly via binding...
8.
Thomas K, Zondler L, Ludwig N, Kardell M, Luneburg C, Henke K, et al.
JCI Insight
. 2022 Sep;
7(21).
PMID: 36107633
Acute kidney injury (AKI) represents a common complication in critically ill patients that is associated with increased morbidity and mortality. In a murine AKI model induced by ischemia/reperfusion injury (IRI),...
9.
Lehmann M, Zarbock A, Rossaint J
Anaesthesiologie
. 2022 Sep;
71(10):741-749.
PMID: 36064976
Background: Acutely occurring organ damage significantly contributes to morbidity and mortality in the perioperative context. Objective: This article highlights new clinical perspectives on how perioperative organ damage can be prevented...
10.
Wienkamp A, Erpenbeck L, Rossaint J
Front Immunol
. 2022 Aug;
13:953129.
PMID: 35979369
Platelets are well characterized for their indispensable role in primary hemostasis to control hemorrhage. Research over the past years has provided a substantial body of evidence demonstrating that platelets also...